Preprint Article Version 1 This version is not peer-reviewed

Visual Evoked Potentials Sensitization/Habituation Mechanisms in Chronic Migraine Patients with or without Medication Overuse

Gianluca Coppola
ORCID logo ,
Francesco Casillo
,
Gabriele Sebastianelli
ORCID logo ,
Chiara Abagnale
,
Cherubino Di Lorenzo
ORCID logo ,
Antonio Di Renzo
,
Mariano Serrao
ORCID logo ,
Vincenzo Parisi
*
Version 1 : Received: 11 September 2024 / Approved: 11 September 2024 / Online: 12 September 2024 (17:49:53 CEST)

How to cite: Coppola, G.; Casillo, F.; Sebastianelli, G.; Abagnale, C.; Di Lorenzo, C.; Di Renzo, A.; Serrao, M.; Parisi, V. Visual Evoked Potentials Sensitization/Habituation Mechanisms in Chronic Migraine Patients with or without Medication Overuse. Preprints 2024, 2024090967. https://doi.org/10.20944/preprints202409.0967.v1 Coppola, G.; Casillo, F.; Sebastianelli, G.; Abagnale, C.; Di Lorenzo, C.; Di Renzo, A.; Serrao, M.; Parisi, V. Visual Evoked Potentials Sensitization/Habituation Mechanisms in Chronic Migraine Patients with or without Medication Overuse. Preprints 2024, 2024090967. https://doi.org/10.20944/preprints202409.0967.v1

Abstract

Background/Objectives: Habituation and sensitization are opposite phenomena that play a role in the pathophysiology of episodic migraine and its progression to chronic migraine (CM). There have been just a few studies that have investigated these phenomena in patients with medication overuse headache (MOH) in comparison to those with chronic migraine (CM) and healthy controls (HCs), and the findings have been inconsistent. Methods: We measured and examined visual evoked potentials (VEPs) in 81 patients with MOH and 24 patients with CM, as well as 24 HCs. The VEPs were used to assess sensitization by analyzing the amplitude of the first block (100 sweeps), and to evaluate habituation by measuring the amplitude response decrement after 6 blocks. We further examined patients diagnosed with MOH based on their acute medication type and after a 3-week acute medication withdrawal program. Results: There were no significant differences between groups in terms of the first N1-P1 VEP amplitude block and its habituation. It was found that patients with MOH had a greater drop in the amplitude of the VEP P1-N2 complex after repeated stimulation than patients with CM or HC. The VEPs parameters showed no significant differences based on the specific overused drug and after a 3-week acute medication off. Conclusions: We propose that the results obtained in patients with MOH indicate an abnormal activation of inhibitory circuits in the parieto-occipital region in response to repeated modulatory stimuli.

Keywords

Medication overuse; chronic migraine; visual cortex; amplitude; medication withdrawal

Subject

Medicine and Pharmacology, Neuroscience and Neurology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Download PDF

Comments (0)

We encourage comments and feedback from a broad range of readers. See criteria for comments and our Diversity statement.

Leave a public comment
Send a private comment to the author(s)
* All users must log in before leaving a comment
Views 0
Downloads 0
Comments 0
Get PDF Cite Share 0
Bookmark BibSonomy Mendeley Reddit Delicious
×
Alerts
Notify me about updates to this article or when a peer-reviewed version is published.
We use cookies on our website to ensure you get the best experience.
Read more about our cookies here.