Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

19G EUS-FNA versus 22G EUS-FNB for Pancreatic Tumors: A Retrospective Comparative Study

Nobuhiro Katsukura
,
Shinpei Doi
* ORCID logo ,
Jun Hayakawa
,
Kanji Okamoto
,
Tomohiro Akutsu
,
Yuta Namura
,
Go Saito
,
Tomohiro Kikuyama
,
Takako Adachi
,
Kotaro Matsumoto
,
Ayako Watanabe
,
Hiromichi Tsunashima
,
Takayuki Tsujikawa
,
Tatsuya Aso
,
Mikiko Takahashi
Version 1 : Received: 11 September 2024 / Approved: 11 September 2024 / Online: 12 September 2024 (11:34:13 CEST)

How to cite: Katsukura, N.; Doi, S.; Hayakawa, J.; Okamoto, K.; Akutsu, T.; Namura, Y.; Saito, G.; Kikuyama, T.; Adachi, T.; Matsumoto, K.; Watanabe, A.; Tsunashima, H.; Tsujikawa, T.; Aso, T.; Takahashi, M. 19G EUS-FNA versus 22G EUS-FNB for Pancreatic Tumors: A Retrospective Comparative Study. Preprints 2024, 2024090975. https://doi.org/10.20944/preprints202409.0975.v1 Katsukura, N.; Doi, S.; Hayakawa, J.; Okamoto, K.; Akutsu, T.; Namura, Y.; Saito, G.; Kikuyama, T.; Adachi, T.; Matsumoto, K.; Watanabe, A.; Tsunashima, H.; Tsujikawa, T.; Aso, T.; Takahashi, M. 19G EUS-FNA versus 22G EUS-FNB for Pancreatic Tumors: A Retrospective Comparative Study. Preprints 2024, 2024090975. https://doi.org/10.20944/preprints202409.0975.v1

Abstract

BACKGROUND: Endoscopic ultrasound-guided tissue acquisition (EUS-TA) is essential technique for sampling solid pancreatic lesions. However, the optimal needle type for achieving high histological diagnostic capability remains unclear. This study compares the histological diagnostic capabilities of the 19G FNA needle and the 22G FNB needle for solid pancreatic lesions. METHODS: This single-center, retrospective study was conducted in patients who underwent EUS-TA for solid pancreatic lesions. Patients were allocated to either Group A, utilizing the 19G FNA needle, or Group B, utilizing the 22G FNB needle. The primary outcome was the diagnostic accuracy based on histology alone. RESULTS: 143 patients were analyzed, with 61 in Group A and 82 in Group B. Diagnostic accuracy was significantly higher in Group B for both histology alone (85.4% vs. 68.9%, p=0.02) and overall diagnostic accuracy (85.4% vs. 73.8%, p=0.02). Logistic regression analysis revealed that lesion size ≥25 mm was an independent factor contributing to higher diagnostic accuracy (OR 3.32, 95% CI 1.28-8.64, p=0.01). Subgroup analysis showed that diagnostic accuracy for 15–25 mm lesions was significantly higher in Group B (90.0% vs. 63.2%, p=0.02). Additionally, trans-gastric punctures had higher accuracy in Group B (94.7% vs. 73.5%, p=0.01). CONCLUSIONS: Our study showed the overall superiority of the 22G FNB needle for EUS-TA of solid pancreatic lesions. However, 19G FNA needle remains a valuable option under specific conditions.

Keywords

endoscopic ultrasound-guided tissue acquisition; solid pancreatic lesions; fine needle aspiration needles; fine needle biopsy needles

Subject

Medicine and Pharmacology, Gastroenterology and Hepatology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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