Version 1
: Received: 7 September 2024 / Approved: 12 September 2024 / Online: 12 September 2024 (12:56:41 CEST)
How to cite:
Kacprzak, B.; Stańczak, M. Knee Joint Response to Mechanical Loading: Bounding Mechanotransduction with Rehabilitation. Preprints2024, 2024090995. https://doi.org/10.20944/preprints202409.0995.v1
Kacprzak, B.; Stańczak, M. Knee Joint Response to Mechanical Loading: Bounding Mechanotransduction with Rehabilitation. Preprints 2024, 2024090995. https://doi.org/10.20944/preprints202409.0995.v1
Kacprzak, B.; Stańczak, M. Knee Joint Response to Mechanical Loading: Bounding Mechanotransduction with Rehabilitation. Preprints2024, 2024090995. https://doi.org/10.20944/preprints202409.0995.v1
APA Style
Kacprzak, B., & Stańczak, M. (2024). Knee Joint Response to Mechanical Loading: Bounding Mechanotransduction with Rehabilitation. Preprints. https://doi.org/10.20944/preprints202409.0995.v1
Chicago/Turabian Style
Kacprzak, B. and Mikołaj Stańczak. 2024 "Knee Joint Response to Mechanical Loading: Bounding Mechanotransduction with Rehabilitation" Preprints. https://doi.org/10.20944/preprints202409.0995.v1
Abstract
The knee joint plays a vital role in human movement, bearing mechanical loads during daily and athletic activities. This review explores the knee joint's response to mechanical loading, particularly focusing on mechanotransduction—the process by which cells convert mechanical stimuli into biochemical signals. These signals trigger cellular responses crucial for maintaining joint health, promoting repair, and adapting to mechanical changes.
Understanding mechanotransduction is key to developing effective rehabilitation strategies for knee injuries and managing conditions like osteoarthritis. This review synthesizes current research on the cellular and molecular pathways involved in knee joint mechanotransduction, examining how various loading conditions—such as compression, tension, and shear—affect tissues like cartilage, synovium, ligaments, and tendons.
The review discusses the impact of mechanotransduction on cellular components such as chondrocytes, synoviocytes, and fibroblasts, which are essential for maintaining tissue integrity and function. It also highlights the role of signaling pathways like MAPK, NF-κB, and Wnt in mediating cellular responses to mechanical stimuli, influencing gene expression, protein synthesis, and metabolism.
By understanding these mechanisms, clinicians can develop targeted therapeutic interventions, including controlled loading protocols, exercise regimens, and manual therapies. This review underscores the importance of integrating mechanobiology insights into rehabilitation practices to enhance tissue repair, restore function, and prevent further joint degeneration, ultimately improving knee joint health and patient outcomes.
Biology and Life Sciences, Biochemistry and Molecular Biology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
