Preprint Article Version 1 This version is not peer-reviewed

Acute Effect of Three Aerobic Exercise Intensities on Glomerular Filtration Rate in Healthy Older Adults

Version 1 : Received: 12 September 2024 / Approved: 12 September 2024 / Online: 13 September 2024 (08:56:43 CEST)

How to cite: Trejo-Trejo, M.; Gomez-Miranda, L. M.; Ramos-Jiménez, A. Acute Effect of Three Aerobic Exercise Intensities on Glomerular Filtration Rate in Healthy Older Adults. Preprints 2024, 2024091031. https://doi.org/10.20944/preprints202409.1031.v1 Trejo-Trejo, M.; Gomez-Miranda, L. M.; Ramos-Jiménez, A. Acute Effect of Three Aerobic Exercise Intensities on Glomerular Filtration Rate in Healthy Older Adults. Preprints 2024, 2024091031. https://doi.org/10.20944/preprints202409.1031.v1

Abstract

No consensus exists on whether acute aerobic exercise alters the glomerular filtration rate in older adults. Objective: To assess the immediate effects of three aerobic exercise intensities on the estimated glomerular filtration rate (eGFR) in healthy, sedentary older adults. Methods: Eighteen healthy, sedentary older adults (12 men and eight women) voluntarily participated in the study. The participants underwent three standardized aerobic exercise tests (100%, 80%, and 60% of the maximal heart rate) on a bicycle ergometer. Blood samples were collected to determine cholesterol, triacylglycerol, glucose, serum creatinine (Cr), Cystatin C (CysC) concentrations, and eGFR. Results: eGFR and serum concentrations of Cr and CysC were not modified at any exercise intensity. There was a negative correlation between blood total cholesterol vs. eGFR (R= -0.512, R= -0.582, R= -0.531; p <0.05) at rest, 60%, and 100% of the maximal heart rate, respectively. Besides, a negative correlation existed between age vs. eGFR at 60% of the maximal heart rate (R= -0.516; p <0.05). Conclusion: Short-time aerobic exercise of low, moderate, and vigorous intensity did not significantly affect eGFR and is considered safe for kidney function in healthy, sedentary older adults.

Keywords

aerobic exercise; cardiovascular risk factors; chronic kidney dysfunction; glomerular filtration rate; sports medicine

Subject

Medicine and Pharmacology, Urology and Nephrology

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