Preprint Review Version 1 This version is not peer-reviewed

The Microbiome in COPD Exacerbations: A Systematic Review

Version 1 : Received: 13 September 2024 / Approved: 13 September 2024 / Online: 13 September 2024 (10:39:24 CEST)

How to cite: Bianca, D.; Rohr, L. V.; Todea, D. The Microbiome in COPD Exacerbations: A Systematic Review. Preprints 2024, 2024091079. https://doi.org/10.20944/preprints202409.1079.v1 Bianca, D.; Rohr, L. V.; Todea, D. The Microbiome in COPD Exacerbations: A Systematic Review. Preprints 2024, 2024091079. https://doi.org/10.20944/preprints202409.1079.v1

Abstract

COPD is a "heterogeneous lung condition characterized by chronic respiratory symptoms. It is a leading cause of death and illness and is associated with a substantial economic burden worldwide. Furthermore, it is marked by frequent exacerbations, which significantly contribute to morbidity and mortality, as well as the overall burden. These exacerbations are frequently triggered by bacterial infections.So far, the most commonly implicated Bacteria are Pseudomonas aeruginosa, Klebsiella pneumoniae, Haemophilus influenzae, Moraxella catarrhalis, and Streptococcus pneumoniae.The advent of culture-independent techniques, such as next-generation sequencing techniques (NGS), allows us to characterise the lung microbiome in different disease states.

Keywords

COPD, the lung microbiome , sequencing of the bacterial 16S ribosomal RNA gene

Subject

Medicine and Pharmacology, Pulmonary and Respiratory Medicine

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