Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Lung Microbiome in Lung Cancer: Composition and Influence – A Systematic Review of Randomised and Non-randomised Trials

Lucaciu Sergiu
,
Domokos Bianca
* ORCID logo ,
Puiu Ruxandra
ORCID logo ,
Ruta Victoria
,
Motoc Nicoleta Stefania
ORCID logo ,
Rajnoveanu Ruxandra
,
Todea Doina
ORCID logo ,
Stoia Mirela Anca
,
Adina Milena Man
ORCID logo
Version 1 : Received: 13 September 2024 / Approved: 13 September 2024 / Online: 14 September 2024 (03:08:32 CEST)

How to cite: Sergiu, L.; Bianca, D.; Ruxandra, P.; Victoria, R.; Stefania, M. N.; Ruxandra, R.; Doina, T.; Anca, S. M.; Man, A. M. Lung Microbiome in Lung Cancer: Composition and Influence – A Systematic Review of Randomised and Non-randomised Trials. Preprints 2024, 2024091080. https://doi.org/10.20944/preprints202409.1080.v1 Sergiu, L.; Bianca, D.; Ruxandra, P.; Victoria, R.; Stefania, M. N.; Ruxandra, R.; Doina, T.; Anca, S. M.; Man, A. M. Lung Microbiome in Lung Cancer: Composition and Influence – A Systematic Review of Randomised and Non-randomised Trials. Preprints 2024, 2024091080. https://doi.org/10.20944/preprints202409.1080.v1

Abstract

To date, the percentage composition of the lung microbiome in bronchopulmonary cancer has not been summarized. Existing studies on identifying the lung microbiome in bronchopulmonary cancer through 16S rRNA sequencing have shown variable results regarding the abundance of bacterial taxa. Objectives: To identify the predominant bacteria in the lung microbiome of bronchopulmonary cancer from samples collected through bronchoalveolar lavage and to assess their potential role in the diagnosis of bronchopulmonary cancers. Data Sources: A systematic review of English articles using MEDLINE, Embase, and Web of Science. Search terms included lung microbiome, lung cancer, bronchoalveolar lavage. Study Selection: Randomized clinical trials that investigated the lung microbiome in bronchopulmonary cancer with samples collected via bronchoalveolar lavage. Data Extraction: Independent extraction of articles using predefined data fields, including study quality indicators. Data Synthesis: Nine studies met the inclusion criteria, focusing on those that utilized a percentage expression of the microbiome at the phylum or genus level. There was noted heterogeneity between studies, both in terms of phylum and genus, with a relatively constant percentage of the Firmicutes phylum and the genera Streptococcus and Veillonella being mentioned. Significant differences were also observed regarding the inclusion criteria for study participants, the method of sample collection, and data processing. Conclusions: To date, there is no consistent percentage pattern at the phylum or genus level in bronchopulmonary cancer, with the predominance of a phylum or genus varying across different patient cohorts, resulting in non-overlapping outcomes.

Keywords

lung microbiome; lung cancer

Subject

Medicine and Pharmacology, Pulmonary and Respiratory Medicine

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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