Preprint Review Version 1 This version is not peer-reviewed

Chronically Increased Levels of Circulating Insulin Secondary to Insulin Resistance: A Silent Killer

Version 1 : Received: 13 September 2024 / Approved: 14 September 2024 / Online: 14 September 2024 (10:27:36 CEST)

How to cite: Fazio, S.; Affuso, F. Chronically Increased Levels of Circulating Insulin Secondary to Insulin Resistance: A Silent Killer. Preprints 2024, 2024091125. https://doi.org/10.20944/preprints202409.1125.v1 Fazio, S.; Affuso, F. Chronically Increased Levels of Circulating Insulin Secondary to Insulin Resistance: A Silent Killer. Preprints 2024, 2024091125. https://doi.org/10.20944/preprints202409.1125.v1

Abstract

This review aims to show, by an analysis of the literature on the topic, that hyperinsulinemia associated with insulin resistance is a multiple risk factor for type 2 diabetes, cardiovascular diseases, cellular senescence and cancer, and neurodegenerative diseases. This condition is progressively increasing in developed and developing countries, and its prevalence has now exceeded 50% of the general population. Since it is asymptomatic or poorly symptomatic, it can last for many years before manifesting itself in the form of type 2 diabetes mellitus, cardiovascular disease, neoplasm, cognitive impairment or dementia, therefore determining enormous social and health care costs. For these reasons, we strongly believe that a screening plan for this pathology should be implemented, in order to identify affected subjects and promptly start them on preventive treatment.

Keywords

insulin resistance; hyperinsulinemia; type 2 diabetes; treatments; adverse effects; risk factor; cardiovascular disease; cellular senescence; cancer; neurodegenerative disease

Subject

Public Health and Healthcare, Public Health and Health Services

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