Version 1
: Received: 16 September 2024 / Approved: 17 September 2024 / Online: 17 September 2024 (08:45:20 CEST)
How to cite:
Anthony, M. R.; Farkouh, C.; Abdi, P.; Amatul-Hadi, F.; Kooner, A.; Dolehide, C. The Intersection of Cancer Biomarkers and Superficial Acral Fibromyxoma: A Review of Literature for Pathologists and Dermatologists. Preprints2024, 2024091281. https://doi.org/10.20944/preprints202409.1281.v1
Anthony, M. R.; Farkouh, C.; Abdi, P.; Amatul-Hadi, F.; Kooner, A.; Dolehide, C. The Intersection of Cancer Biomarkers and Superficial Acral Fibromyxoma: A Review of Literature for Pathologists and Dermatologists. Preprints 2024, 2024091281. https://doi.org/10.20944/preprints202409.1281.v1
Anthony, M. R.; Farkouh, C.; Abdi, P.; Amatul-Hadi, F.; Kooner, A.; Dolehide, C. The Intersection of Cancer Biomarkers and Superficial Acral Fibromyxoma: A Review of Literature for Pathologists and Dermatologists. Preprints2024, 2024091281. https://doi.org/10.20944/preprints202409.1281.v1
APA Style
Anthony, M. R., Farkouh, C., Abdi, P., Amatul-Hadi, F., Kooner, A., & Dolehide, C. (2024). The Intersection of Cancer Biomarkers and Superficial Acral Fibromyxoma: A Review of Literature for Pathologists and Dermatologists. Preprints. https://doi.org/10.20944/preprints202409.1281.v1
Chicago/Turabian Style
Anthony, M. R., Amritpal Kooner and Conor Dolehide. 2024 "The Intersection of Cancer Biomarkers and Superficial Acral Fibromyxoma: A Review of Literature for Pathologists and Dermatologists" Preprints. https://doi.org/10.20944/preprints202409.1281.v1
Abstract
Superficial acral fibromyxoma (SAF) is a benign fibromyxoid tumor that presents as a slow-growing nodule on the subungual and periungual areas of the hands and feet. Superficial acral fibromyxoma needs to be better documented in the literature, and thus, increased research and education are required to aid clinicians in recognizing its appearance. To review the current literature on superficial acral fibromyxoma and present its epidemiology, pathogenesis, clinical presentation, diagnosis, treatment, and common differential diagnosis. A literature review was performed on Pubmed and Scopus for case reports, case series, clinical studies, and reviews that described epidemiology, clinical presentation, pathogenesis, histological examination, and treatment of superficial acral fibromyxoma. The gathered literature was analyzed to extract concise information on superficial acral fibromyxoma. Results: Superficial acral fibromyxoma is associated with Rb1 gene deletion and grows as a 0.5 to 5.0-centimeter gelatinous-to-firm nodular mass on periungual or subungual regions of middle-aged males. It is also noted to disrupt nail architecture and cause lytic or erosive lesions of bone. Histopathologically, superficial acral fibromyxoma comprises stellate and spindle cells surrounded by a myxo-collagenous matrix and is strongly positive for CD34, CD99, nestin, and vimentin. Complete surgical excision is the first-line treatment for superficial acral fibromyxoma; however, the tumor has a post-operative recurrence rate of 20-25%. Mohs surgery has been attempted to decrease the rate of recurrence. After excluding other cutaneous neoplasms, superficial acral fibromyxoma should be considered in patients with a periungual or subungual slow-growing mass and other soft tissue. Complete surgical excision can lead to recurrence; therefore, patient follow-up is necessary.
Biology and Life Sciences, Biology and Biotechnology
Copyright:
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