Version 1
: Received: 17 September 2024 / Approved: 18 September 2024 / Online: 19 September 2024 (08:43:49 CEST)
How to cite:
Bibire, T.; Timofte, D. V.; Dănilă, R.; Panainte, A. D.; Yilmaz, C. N.; Bibire, N.; Agoroaei, L.; Ghiciuc, C. M. Rifampicin Loaded PLGA/Alginate Grafted pNVCL-Based Nanoparticles for Wound Healing. Preprints2024, 2024091365. https://doi.org/10.20944/preprints202409.1365.v1
Bibire, T.; Timofte, D. V.; Dănilă, R.; Panainte, A. D.; Yilmaz, C. N.; Bibire, N.; Agoroaei, L.; Ghiciuc, C. M. Rifampicin Loaded PLGA/Alginate Grafted pNVCL-Based Nanoparticles for Wound Healing. Preprints 2024, 2024091365. https://doi.org/10.20944/preprints202409.1365.v1
Bibire, T.; Timofte, D. V.; Dănilă, R.; Panainte, A. D.; Yilmaz, C. N.; Bibire, N.; Agoroaei, L.; Ghiciuc, C. M. Rifampicin Loaded PLGA/Alginate Grafted pNVCL-Based Nanoparticles for Wound Healing. Preprints2024, 2024091365. https://doi.org/10.20944/preprints202409.1365.v1
APA Style
Bibire, T., Timofte, D. V., Dănilă, R., Panainte, A. D., Yilmaz, C. N., Bibire, N., Agoroaei, L., & Ghiciuc, C. M. (2024). Rifampicin Loaded PLGA/Alginate Grafted pNVCL-Based Nanoparticles for Wound Healing. Preprints. https://doi.org/10.20944/preprints202409.1365.v1
Chicago/Turabian Style
Bibire, T., Luminita Agoroaei and Cristina Mihaela Ghiciuc. 2024 "Rifampicin Loaded PLGA/Alginate Grafted pNVCL-Based Nanoparticles for Wound Healing" Preprints. https://doi.org/10.20944/preprints202409.1365.v1
Abstract
The topical therapy with rifampicin (RF)-based formulations is beneficial to treat infections and to healing the wounds. Despite recent research highlighting the antibiotic's significant an-ti-inflammatory properties, limited topical wound healing products are currently available. Present study aimed to prove that the newly synthesized nanoparticles based on grafted alginate and poly(N-vinylcaprolactam (pNVCL) and poly-lactic-co-glycolic acid (PLGA) contributes to the healing process of a wound. The methods used were at first the synthesis of the copolymer of al-ginate and pNVCL via grafting from technique and radical polymerization followed by wa-ter-in-oil-in water (W/O/W) emulsification by using as oil phase PLGA dissolved in dichloromethane (DCM). The formed nanoparticles were than characterized. The loaded RF was determined to be 160 µg/mL for a 20 mg formulation and within a four-hour time frame approximately 10% of the total loaded amount was released. The inhibitory concentrations (IC50) were 192 µg/mL for the nanoparticle, 208 µg/mL for pure rifampicin, and 718 µg/mL for the rifampicin-loaded nanopar-ticles. Considering the double role Rifampicin was used for, the result was considered satisfactory in the way that these formulations could be used more with the wound irrigation post-surgery to avoid infections and to contribute to the healing.
Public Health and Healthcare, Public Health and Health Services
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
,
*
,
,
,
