Version 1
: Received: 18 September 2024 / Approved: 18 September 2024 / Online: 19 September 2024 (03:41:11 CEST)
How to cite:
Nieto, S.; Lozano, I.; Ruiz, F. J.; Costa, J. F.; Villa, R.; Lozano, P. Sustainable Synthesis of New Antioxidants from Hydroxytyrosol by Direct Biocatalytic Esterification in Ionic Liquids. Preprints2024, 2024091423. https://doi.org/10.20944/preprints202409.1423.v1
Nieto, S.; Lozano, I.; Ruiz, F. J.; Costa, J. F.; Villa, R.; Lozano, P. Sustainable Synthesis of New Antioxidants from Hydroxytyrosol by Direct Biocatalytic Esterification in Ionic Liquids. Preprints 2024, 2024091423. https://doi.org/10.20944/preprints202409.1423.v1
Nieto, S.; Lozano, I.; Ruiz, F. J.; Costa, J. F.; Villa, R.; Lozano, P. Sustainable Synthesis of New Antioxidants from Hydroxytyrosol by Direct Biocatalytic Esterification in Ionic Liquids. Preprints2024, 2024091423. https://doi.org/10.20944/preprints202409.1423.v1
APA Style
Nieto, S., Lozano, I., Ruiz, F. J., Costa, J. F., Villa, R., & Lozano, P. (2024). Sustainable Synthesis of New Antioxidants from Hydroxytyrosol by Direct Biocatalytic Esterification in Ionic Liquids. Preprints. https://doi.org/10.20944/preprints202409.1423.v1
Chicago/Turabian Style
Nieto, S., Rocio Villa and Pedro Lozano. 2024 "Sustainable Synthesis of New Antioxidants from Hydroxytyrosol by Direct Biocatalytic Esterification in Ionic Liquids" Preprints. https://doi.org/10.20944/preprints202409.1423.v1
Abstract
Hydroxytyrosol (HT) is a nutraceutic compound, mainly found in the fruit, leaves and waste from the olive oil industry, that shows one of the highest antioxidant activities among molecules of natural origin. To harness this bioactivity in cosmetics, pharmaceuticals, and the food industry, it is essential to modify the hydrophilicity of HT to enhance its compatibility with lipid-based mixtures. This chemical modification must be done with high selectivity to avoid compromising its radical scavenging activity. This work presents a highly efficient and selective approach to perform the biocatalytic esterification of free fatty acids (FFAs) of different alkyl chain length with HT in a reaction medium based on the SLIL [C12mim][NTf2]. By using a 1:2 (mol/mol) HT:FFA mixture of substrates, the HT monoester derivative was obtained up to 77% yield after 2 h at 80 oC. The adjusted molar ratio of substrates, combined with the ability to recover the SLIL for further reuse, significantly reduces waste accumulation compared to other reported strategies and results in a more sustainable approach as demonstrated by different green metrics. Furthermore, it was demonstrated by a DPPH test how the HT monoester products retain the same antioxidant activity as free HT, being superior to vitamin C.
Keywords
hydroxytyrosol; applied biocatalysis; green processes; sponge-like ionic liquids; antioxidants
Subject
Chemistry and Materials Science, Applied Chemistry
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.