Preprint Article Version 1 This version is not peer-reviewed

Chiral Sodium Glicerophosphate Catalyst for Enantioselective Michael Reactions of Chalcones

Version 1 : Received: 18 September 2024 / Approved: 18 September 2024 / Online: 18 September 2024 (15:34:19 CEST)

How to cite: Ghigo, G.; Rivella, J.; Robiolio Bose, A.; Dughera, S. Chiral Sodium Glicerophosphate Catalyst for Enantioselective Michael Reactions of Chalcones. Preprints 2024, 2024091427. https://doi.org/10.20944/preprints202409.1427.v1 Ghigo, G.; Rivella, J.; Robiolio Bose, A.; Dughera, S. Chiral Sodium Glicerophosphate Catalyst for Enantioselective Michael Reactions of Chalcones. Preprints 2024, 2024091427. https://doi.org/10.20944/preprints202409.1427.v1

Abstract

A chiral sodium glicerophosphate is successfully exploited as catalyst in Michael addition of methyl malonate to a number of chalcones. The reactions furnished the target adducts in satisfactory yields and good enantiomeric excesses. A tentative of computational study is presented aiming to understand the reaction mechanism.

Keywords

conjugate addition; organocatalyst; chiral catalyst

Subject

Chemistry and Materials Science, Organic Chemistry

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