Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Long-Term Effects of Symbiotic Supplementation at Different Rearing Stages on Serum Biochemistry and Clostridium perfringens Antibiotic Resistance in Laying Hens

Webert Aurino da Silva
* ,
Carlos Bôa-Viagem Rabello
,
Lilian Francisco Arantes de Souza
* ,
Júlio Cézar dos Santos Nascimento
ORCID logo ,
Marcos José Batista dos Santos
ORCID logo ,
Mércia Rodrigues Barros
,
Miriam Nascimento Teixeira
,
Daniela Pinheiro de Oliveira
ORCID logo ,
Apolônio Gomes Ribeiro
ORCID logo ,
Dayane Albuquerque da Silva
,
Saruanna Millena dos Santos Clemente
Version 1 : Received: 18 September 2024 / Approved: 19 September 2024 / Online: 19 September 2024 (08:08:29 CEST)

How to cite: Silva, W. A. D.; Rabello, C. B.-V.; Souza, L. F. A. D.; Nascimento, J. C. D. S.; Santos, M. J. B. D.; Barros, M. R.; Teixeira, M. N.; Oliveira, D. P. D.; Ribeiro, A. G.; Silva, D. A. D.; Clemente, S. M. D. S. Long-Term Effects of Symbiotic Supplementation at Different Rearing Stages on Serum Biochemistry and Clostridium perfringens Antibiotic Resistance in Laying Hens. Preprints 2024, 2024091472. https://doi.org/10.20944/preprints202409.1472.v1 Silva, W. A. D.; Rabello, C. B.-V.; Souza, L. F. A. D.; Nascimento, J. C. D. S.; Santos, M. J. B. D.; Barros, M. R.; Teixeira, M. N.; Oliveira, D. P. D.; Ribeiro, A. G.; Silva, D. A. D.; Clemente, S. M. D. S. Long-Term Effects of Symbiotic Supplementation at Different Rearing Stages on Serum Biochemistry and Clostridium perfringens Antibiotic Resistance in Laying Hens. Preprints 2024, 2024091472. https://doi.org/10.20944/preprints202409.1472.v1

Abstract

This study evaluated the effects of replacing zinc bacitracin with a symbiotic diet on the biochemical profile, liver development, and Clostridium perfringens presence in laying hens at 90 weeks of age. A total of 198 Dekalb–White hens were assigned to six experimental diets: MBM (corn, soybean meal, and meat and bone meal), BAC (MBM + 0.05% zinc bacitracin), and SIMC (MBM + 0.1% symbiotic), provided from day 1 to 90 weeks. Additional treatments, SIMR and SIMP, received symbiotics from weeks 6 and 17, re-spectively. At 90 weeks, blood and tissue samples were analyzed. Results showed that symbiotic-treated hens had 20% heavier livers (P < 0.01) and lower concentrations of uric acid, total proteins, AST, ALT, and LDH (P < 0.01) compared to BAC-treated birds. Phosphorus, triglycerides, and HDL levels were better in symbiotic groups. C. perfringens counts and antibiotic resistance (ampicillin, erythromycin, aminoglyco-sides, lincomycin, tetracycline, bacitracin) were significantly higher in BAC groups (P < 0.01). Symbiotic supplementation improved intestinal health, reduced pathogenic bacterial colonization, and enhanced liver function compared to continuous antibiotic use, especially when administered from early life stages.

Keywords

Prebiotic; Probiotic; Liver health

Subject

Biology and Life Sciences, Agricultural Science and Agronomy

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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