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Dietary Supplementation of Pistacia lentiscus L.,: An Hepato-protective Potential Against 7,12-dimethylbenz(a)anthracene Carcinogen in C57BL/6 Mice, Alongside In Vitro Anti-Cancer Efficacy
ABIDI, O.; Hammami, I.; Jebali, J.; Srairi-Abid, N.; Alqahtani, A. S.; Gressier, B.; Eto, B.; SOUILEM, O. Dietary Supplementation of Pistacia lentiscus L.,: An Hepato-protective Potential Against 7,12-dimethylbenz(a)anthracene Carcinogen in C57BL/6 Mice, Alongside In Vitro Anti-Cancer Efficacy. Preprints2024, 2024091480. https://doi.org/10.20944/preprints202409.1480.v1
APA Style
ABIDI, O., Hammami, I., Jebali, J., Srairi-Abid, N., Alqahtani, A. S., Gressier, B., Eto, B., & SOUILEM, O. (2024). Dietary Supplementation of Pistacia lentiscus L.,: An Hepato-protective Potential Against 7,12-dimethylbenz(a)anthracene Carcinogen in C57BL/6 Mice, Alongside In Vitro Anti-Cancer Efficacy. Preprints. https://doi.org/10.20944/preprints202409.1480.v1
Chicago/Turabian Style
ABIDI, O., Bruno Eto and Ouajdi SOUILEM. 2024 "Dietary Supplementation of Pistacia lentiscus L.,: An Hepato-protective Potential Against 7,12-dimethylbenz(a)anthracene Carcinogen in C57BL/6 Mice, Alongside In Vitro Anti-Cancer Efficacy" Preprints. https://doi.org/10.20944/preprints202409.1480.v1
Abstract
The pervasive presence of atmospheric pollution, particularly polycyclic aromatic hydrocarbons such as 7,12-dimethylbenz(a)anthracene, instigates aberrant cellular and tissue conditions, precipitating oxidative damage and inflammatory cascades conducive to the onset of cancer, notably mammary cancer. Given the hepatic metabolism of 7,12-dimethylbenz(a)anthracene, liver damage can be found and the imperative of employing natural antioxidants becomes apparent. In this study, we first showed that 7,12-dimethylbenz(a)anthracene-intoxication escalates body weight, disrupts lipid profiles, and incites serum oxidative damage. Concurrently, hepatic and renal oxidative stress ensue, accompanied by heightened antioxidant enzyme activity in the 7,12-dimethylbenz(a)anthracene-exposed group compared to controls (p<0.05). Interestingly, P.lentiscus co-administration rectifies biochemical imbalances, significantly attenuates oxidative stress aberrations, and augments antioxidant enzyme responses (p<0.05). Importantly, histological analysis evinces P.lentiscus's shielding effect against 7,12-dimethylbenz(a)anthracene induced hepatocyte injury and steatosis. Furthermore, our investigations unveil P.lentiscus’s anti-proliferative efficacy against different human breast cancer cell lines. Thus, our findings underscore P.lentiscus‘s robust anti-proliferative, antioxidant, and hepato-protective capacities, mitigating metabolic disturbances, oxidative stress propagation in liver and kidney functions, and potential histological alterations, thereby impeding 7,12-dimethylbenz(a)anthracene induced mammary cancer initiation. We posit that P.lentiscus may serve as a prophylactic agent against breast cancer and liver oxidative damage instigated by this carcinogen.
Medicine and Pharmacology, Dietetics and Nutrition
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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