Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Chronic Rheumatologic Disease in Chikungunya Virus Fever: Results from a Cohort Study Conducted in Piedecuesta, Colombia

Anyela Lozano-Parra
,
Víctor Herrera
ORCID logo ,
Carlos Calderón
,
Reynaldo Badillo
,
Rosa Margarita Gélvez Ramírez
,
María Isabel Estupiñán Cárdenas
,
José Fernando Lozano Jiménez
,
Luis Ángel Villar
ORCID logo ,
Elsa Marina Rojas Garrido
* ORCID logo
Version 1 : Received: 18 September 2024 / Approved: 19 September 2024 / Online: 19 September 2024 (12:21:04 CEST)

How to cite: Lozano-Parra, A.; Herrera, V.; Calderón, C.; Badillo, R.; Gélvez Ramírez, R. M.; Estupiñán Cárdenas, M. I.; Lozano Jiménez, J. F.; Villar, L. Á.; Rojas Garrido, E. M. Chronic Rheumatologic Disease in Chikungunya Virus Fever: Results from a Cohort Study Conducted in Piedecuesta, Colombia. Preprints 2024, 2024091519. https://doi.org/10.20944/preprints202409.1519.v1 Lozano-Parra, A.; Herrera, V.; Calderón, C.; Badillo, R.; Gélvez Ramírez, R. M.; Estupiñán Cárdenas, M. I.; Lozano Jiménez, J. F.; Villar, L. Á.; Rojas Garrido, E. M. Chronic Rheumatologic Disease in Chikungunya Virus Fever: Results from a Cohort Study Conducted in Piedecuesta, Colombia. Preprints 2024, 2024091519. https://doi.org/10.20944/preprints202409.1519.v1

Abstract

This study aimed to determine the incidence of post-chikungunya chronic rheumatism (pCHIK-CR) its impact on quality of life (QoL) and chronic fatigue in adult seven years after the 2014-2015 CHIKV outbreak in Piedecuesta, Colombia. We evaluated 78 adults (median age: 30 years, IQR: 21.0; women 60.3%) with confirmed CHIKV infection. In 2022, participants underwent a GALS examination and completed surveys on disability, stiffness, health status, and fatigue. A rheumatologist evaluated patients who reported arthralgia, morning stiffness, and abnormal GALS examination. Chronic fatigue was defined as fatigue persisting for over six months. Seven years after infection, 14.1% of participants were classified as pCHIK-CR cases, 41.0% as having non-inflammatory pain likely degenerative (NIP-LD), and 44.9% without rheumatic disease (Wo-RM). Patients with pCHIK-CR and NIP-LD exhibited significantly worse QoL compared to Wo-RM cases. Chronic fatigue prevalence increased from 8.6% in Wo-RM patients to 25.0% in NIP-LD and 54.6% in pCHIK-CR cases. This study implemented a comprehensive clinical as-sessment to objectively estimate and characterize the incidence of chronic rheumatological disease attributed to CHIKV infection. One in seven cases with CHIKV infection develops pCHIK-CR, which impacts both QoL and chronic fatigue. This study contributes to understanding the burden of these arboviruses in the medium term.

Keywords

Chikungunya; chronic rheumatism; rheumatic disease; fatigue; quality of life

Subject

Medicine and Pharmacology, Epidemiology and Infectious Diseases

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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