Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Autism Spectrum Disorder Pathogenesis – a Cross-Sectional Literature Review with Emphasis to Molecular Aspect

Version 1 : Received: 20 September 2024 / Approved: 23 September 2024 / Online: 24 September 2024 (09:02:45 CEST)

How to cite: Horecka-Lewitowicz, A.; Lewitowicz, W.; Wawszczak-Kasza, M.; Lim, H.; Piotr, L. Autism Spectrum Disorder Pathogenesis – a Cross-Sectional Literature Review with Emphasis to Molecular Aspect. Preprints 2024, 2024091776. https://doi.org/10.20944/preprints202409.1776.v1 Horecka-Lewitowicz, A.; Lewitowicz, W.; Wawszczak-Kasza, M.; Lim, H.; Piotr, L. Autism Spectrum Disorder Pathogenesis – a Cross-Sectional Literature Review with Emphasis to Molecular Aspect. Preprints 2024, 2024091776. https://doi.org/10.20944/preprints202409.1776.v1

Abstract

The etiology of autism spectrum disorder (ASD) has not yet been completely elucidated. Through time, multiple attempts have been made to uncover the causes of ASD. Different theories have been proposed, such as that it is caused by “Gods Wrath,” alterations in the gut–brain axis with an emphasis on gut dysbiosis, post vaccine complications, and genetic or even autoimmune causes. In this review we present data covering over 170 000 participants at age ranging from 2 to 14 years focusing on human cell changes rather than using animal models found in previous studies. The male/female ratio was 4:1. Data collection occurred in many countries covering ethnically diversified subjects. Moreover, we aimed to show how the progress in genetic techniques influences the explanation of medical White Papers in ASD area.

Keywords

keyword ASD; Asperger syndrome; autism; molecular sequencing

Subject

Medicine and Pharmacology, Psychiatry and Mental Health

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