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The Efficacy of Topically Applied Curcumin 1% as Alternative or Complementary to Triamcinolone Acetonate in Treatment of Oral Lichen Planus (Randomize Control Trial)
Version 1
: Received: 23 September 2024 / Approved: 23 September 2024 / Online: 24 September 2024 (00:17:02 CEST)
How to cite:
Kotb, S.; Alaa El Din, B.; Edrees, M. The Efficacy of Topically Applied Curcumin 1% as Alternative or Complementary to Triamcinolone Acetonate in Treatment of Oral Lichen Planus (Randomize Control Trial). Preprints2024, 2024091822. https://doi.org/10.20944/preprints202409.1822.v1
Kotb, S.; Alaa El Din, B.; Edrees, M. The Efficacy of Topically Applied Curcumin 1% as Alternative or Complementary to Triamcinolone Acetonate in Treatment of Oral Lichen Planus (Randomize Control Trial). Preprints 2024, 2024091822. https://doi.org/10.20944/preprints202409.1822.v1
Kotb, S.; Alaa El Din, B.; Edrees, M. The Efficacy of Topically Applied Curcumin 1% as Alternative or Complementary to Triamcinolone Acetonate in Treatment of Oral Lichen Planus (Randomize Control Trial). Preprints2024, 2024091822. https://doi.org/10.20944/preprints202409.1822.v1
APA Style
Kotb, S., Alaa El Din, B., & Edrees, M. (2024). The Efficacy of Topically Applied Curcumin 1% as Alternative or Complementary to Triamcinolone Acetonate in Treatment of Oral Lichen Planus (Randomize Control Trial). Preprints. https://doi.org/10.20944/preprints202409.1822.v1
Chicago/Turabian Style
Kotb, S., Barra Alaa El Din and Mohamed Edrees. 2024 "The Efficacy of Topically Applied Curcumin 1% as Alternative or Complementary to Triamcinolone Acetonate in Treatment of Oral Lichen Planus (Randomize Control Trial)" Preprints. https://doi.org/10.20944/preprints202409.1822.v1
Abstract
Aim of study: to evaluate the therapeutic impact of topically applied curcumin as Alternative or Complementary to Triamcinolone Acetonate in Treatment of Oral Lichen Planus. Background: Oral lichen planus (OLP) is a chronic inflammatory disorder affecting the mucous membranes, believed to be an immune-mediated condition. Its persisting nature can lead to extended discomfort for those affected. The primary symptoms are pain and a burning sensation, with a potential risk of malignancy if not properly managed, necessitating lifelong clinical monitoring. Presently, OLP is considered a significant challenge due to the absence of a definitive cure. Patients & patients: Thirty patients with oral lichen planus were divided into three groups, 10 patients each: Group A: ten patients with OLP were received topical triamcinolone acetonide. Group B: ten patients with OLP were received topical curcumin. Group C: ten patients with oral lichen planus were received topical triamcinolone acetonide combiend with topical curcumin. For six weeks. Each patient was examined at baseline, 1 and 3months of therapy. Pain was scored using the visual analogue scale. Salivary level of interleukin 6 were estimated at baseline, 1 and 3months evaluation periods. Results: Significant decrease in pain score was observed in all groups and there was a statistically significant difference between them at all treatment periods in favor to group C . 2 Additionally, all groups showed a decrease in the size of lesions which was greater in group A,C compared to the B group. A significant reduction of the mean interlukin6 continued down to 3 months in all groups with statistically insignificant difference between them at three months, while statistically significant difference in favor to group C at 1month was observed. Conclusion: The results proved the benefit of curcumin as a promising medication when used in combination with conventional therapy in treatment of OLP patients. However, further longterm studies with large sample size are needed.
Medicine and Pharmacology, Dentistry and Oral Surgery
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
