Version 1
: Received: 24 September 2024 / Approved: 24 September 2024 / Online: 25 September 2024 (04:24:34 CEST)
How to cite:
Elbahlawan, L.; Qudeimat, A.; Morrison, R.; Schaller, A. Fluid Overload in Children Following Hematopoietic Cell Transplant: A Cause for Concern?. Preprints2024, 2024091934. https://doi.org/10.20944/preprints202409.1934.v1
Elbahlawan, L.; Qudeimat, A.; Morrison, R.; Schaller, A. Fluid Overload in Children Following Hematopoietic Cell Transplant: A Cause for Concern?. Preprints 2024, 2024091934. https://doi.org/10.20944/preprints202409.1934.v1
Elbahlawan, L.; Qudeimat, A.; Morrison, R.; Schaller, A. Fluid Overload in Children Following Hematopoietic Cell Transplant: A Cause for Concern?. Preprints2024, 2024091934. https://doi.org/10.20944/preprints202409.1934.v1
APA Style
Elbahlawan, L., Qudeimat, A., Morrison, R., & Schaller, A. (2024). Fluid Overload in Children Following Hematopoietic Cell Transplant: A Cause for Concern?. Preprints. https://doi.org/10.20944/preprints202409.1934.v1
Chicago/Turabian Style
Elbahlawan, L., Ray Morrison and Alexandra Schaller. 2024 "Fluid Overload in Children Following Hematopoietic Cell Transplant: A Cause for Concern?" Preprints. https://doi.org/10.20944/preprints202409.1934.v1
Abstract
Fluid overload significantly increases morbidity and mortality in critically ill children. Following hematopoietic cell transplant (HCT), children are at high risk of fluid ac-cumulation due to essential increased fluid intake for nutrition, blood products, and antimicrobials. In addition, many complications predispose these children to capillary leak and fluid overload (FO), such as sinusoidal obstruction syndrome, engraftment syndrome, sepsis, and acute kidney injury (AKI). FO>10 % occurs in nearly half of children following HCT and is associated with a lower PICU survival rate. In addition, in children with acute respiratory failure post HCT, each 1% increase in cumulative fluid balance on d 3 increased the odds of PICU mortality by 3%. Furthermore, FO worsens AKI. Tools such as the renal angina index and urinary biomarkers such as neutrophil gelatinase-associated lipocalin can help identify patients at risk of AKI and FO. Early detection, prevention, and intervention are crucial to improving outcome in this population. Management strategies include fluid restriction, diuretics, and continuous kidney replacement therapy (CKRT) when FO exceeds 10% and other measures have failed. Children with FO > 10% at CKRT initiation were 6.16 times more likely to die than were those with FO ≤ 10%.
Medicine and Pharmacology, Pediatrics, Perinatology and Child Health
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
