Version 1
: Received: 25 September 2024 / Approved: 25 September 2024 / Online: 25 September 2024 (12:06:29 CEST)
How to cite:
Roth, T.; Zelinger, E.; Kossovsky, T.; Borkow, G. Microscopy Analysis of the Effect on Biofilm Covered Bacteria Exposed to Wound Dressings Impregnated with Cuprous Oxide Microparticles. Preprints2024, 2024092003. https://doi.org/10.20944/preprints202409.2003.v1
Roth, T.; Zelinger, E.; Kossovsky, T.; Borkow, G. Microscopy Analysis of the Effect on Biofilm Covered Bacteria Exposed to Wound Dressings Impregnated with Cuprous Oxide Microparticles. Preprints 2024, 2024092003. https://doi.org/10.20944/preprints202409.2003.v1
Roth, T.; Zelinger, E.; Kossovsky, T.; Borkow, G. Microscopy Analysis of the Effect on Biofilm Covered Bacteria Exposed to Wound Dressings Impregnated with Cuprous Oxide Microparticles. Preprints2024, 2024092003. https://doi.org/10.20944/preprints202409.2003.v1
APA Style
Roth, T., Zelinger, E., Kossovsky, T., & Borkow, G. (2024). Microscopy Analysis of the Effect on Biofilm Covered Bacteria Exposed to Wound Dressings Impregnated with Cuprous Oxide Microparticles. Preprints. https://doi.org/10.20944/preprints202409.2003.v1
Chicago/Turabian Style
Roth, T., Tally Kossovsky and Gadi Borkow. 2024 "Microscopy Analysis of the Effect on Biofilm Covered Bacteria Exposed to Wound Dressings Impregnated with Cuprous Oxide Microparticles" Preprints. https://doi.org/10.20944/preprints202409.2003.v1
Abstract
Microbial infections in wounds can significantly delay the healing process, with bacteria often forming protective biofilms that shield them from external threats. In this study, we evaluated the impact of copper oxide-impregnated wound dressings (referred to as COD) on a bacterial mixture comprising common gram-positive and gram-negative wound pathogens encased in biofilm. The bacterial mix was exposed to COD or control dressings for 0, 1, 2, and 3 hours, and the effects were analyzed using scanning electron microscopy. After just 1 hour of exposure to COD, notable leakage of bacterial cytoplasmic contents was observed. By the 3-hour mark, the gram-negative bacteria exhibited formation of holes in their cell walls, while gram-positive bacteria showed a reduction in cell width. These findings demonstrate the ability of COD to effectively kill bacteria, even when protected by biofilm, supporting clinical observations of its efficacy in managing infected wounds.
Biology and Life Sciences, Immunology and Microbiology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
