Version 1
: Received: 26 September 2024 / Approved: 27 September 2024 / Online: 27 September 2024 (07:07:14 CEST)
How to cite:
Wang, B. X. Investigating Inherited Heart Diseases Using Human Induced Pluripotent Stem Cells. Preprints2024, 2024092169. https://doi.org/10.20944/preprints202409.2169.v1
Wang, B. X. Investigating Inherited Heart Diseases Using Human Induced Pluripotent Stem Cells. Preprints 2024, 2024092169. https://doi.org/10.20944/preprints202409.2169.v1
Wang, B. X. Investigating Inherited Heart Diseases Using Human Induced Pluripotent Stem Cells. Preprints2024, 2024092169. https://doi.org/10.20944/preprints202409.2169.v1
APA Style
Wang, B. X. (2024). Investigating Inherited Heart Diseases Using Human Induced Pluripotent Stem Cells. Preprints. https://doi.org/10.20944/preprints202409.2169.v1
Chicago/Turabian Style
Wang, B. X. 2024 "Investigating Inherited Heart Diseases Using Human Induced Pluripotent Stem Cells" Preprints. https://doi.org/10.20944/preprints202409.2169.v1
Abstract
Inherited heart diseases (IHDs) are caused by genetic mutations that disrupt the physiological structure and function of the heart. Understanding the mechanisms behind these diseases is crucial for developing personalised interventions in cardiovascular medicine. Development of induced pluripotent stem cells, which can then be differentiated to any nucleated adult cell type, has enabled the creation of personalised single-cell and multicellular models, providing unprecedented insights into the pathophysiology of IHDs. This review provides a comprehensive overview of recent advancements in human iPSC models used to dissect the molecular and genetic underpinnings of common IHDs. We examine multicellular models and tissue engineering approaches, such as cardiac organoids, engineered heart tissue, and multicellular co-culture systems, which simulate complex intercellular interactions within heart tissue. Recent advancements in stem cell models offer a more physiologically relevant platform to study disease mechanisms, enabling researchers to observe cellular interactions, study disease progression, and identify therapeutic strategies. By leveraging these innovative models, we can gain deeper insights into the molecular and cellular mechanisms underlying IHDs, ultimately paving the way for more effective diagnostic and therapeutic strategies.
Medicine and Pharmacology, Cardiac and Cardiovascular Systems
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
