Preprint Communication Version 1 This version is not peer-reviewed

New Allyl Derivative of Curcumin: Synthesis and Crystal Structure of (1E, 6E)-4-Allyl-1,7-bis(4′-Allyloxy-3′-Methoxyphenyl)hepta-1,6-Diene-3,5-Dione

Version 1 : Received: 26 September 2024 / Approved: 27 September 2024 / Online: 27 September 2024 (05:47:32 CEST)

How to cite: Druzina, A. A.; Zhidkova, O. B.; Anufriev, S. A.; Dubasova, E. V.; Ananyev, I. V.; Banerjee, S.; Sivaev, I. B.; Bregadze, V. I. New Allyl Derivative of Curcumin: Synthesis and Crystal Structure of (1E, 6E)-4-Allyl-1,7-bis(4′-Allyloxy-3′-Methoxyphenyl)hepta-1,6-Diene-3,5-Dione. Preprints 2024, 2024092182. https://doi.org/10.20944/preprints202409.2182.v1 Druzina, A. A.; Zhidkova, O. B.; Anufriev, S. A.; Dubasova, E. V.; Ananyev, I. V.; Banerjee, S.; Sivaev, I. B.; Bregadze, V. I. New Allyl Derivative of Curcumin: Synthesis and Crystal Structure of (1E, 6E)-4-Allyl-1,7-bis(4′-Allyloxy-3′-Methoxyphenyl)hepta-1,6-Diene-3,5-Dione. Preprints 2024, 2024092182. https://doi.org/10.20944/preprints202409.2182.v1

Abstract

New allyl derivative of curcumin containing three allyl groups (1E,6E)-4-allyl-1,7-bis(4’-allyloxy-3’-methoxyphenyl)hepta-1,6-diene-3,5-dione was synthesized by the reaction of curcumin with the excess of allyl bromide in the presence of K2CO3 in acetone under reflux. The triple allylated curcumin was characterized by 1H and 13C NMR spectroscopy and single-crystal X-ray diffraction study.

Keywords

curcumin; allyl derivative; synthesis; NMR spectra; single crystal X-ray diffraction

Subject

Chemistry and Materials Science, Organic Chemistry

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