Preprint Article Version 1 This version is not peer-reviewed

Quantitative Multi-Parametric MRI of the Prostate Reveals Racial Differences

Aritrick Chatterjee
* ,
Xiaobing Fan
,
Jessica Slear
,
Greg Asare
,
Ambereen Yousuf
,
Milica Medved
,
Tatjana Antic
,
Scott Eggener
,
Gregory S Karczmar
,
Aytekin Oto
Version 1 : Received: 26 September 2024 / Approved: 27 September 2024 / Online: 27 September 2024 (14:44:14 CEST)

How to cite: Chatterjee, A.; Fan, X.; Slear, J.; Asare, G.; Yousuf, A.; Medved, M.; Antic, T.; Eggener, S.; Karczmar, G. S.; Oto, A. Quantitative Multi-Parametric MRI of the Prostate Reveals Racial Differences. Preprints 2024, 2024092234. https://doi.org/10.20944/preprints202409.2234.v1 Chatterjee, A.; Fan, X.; Slear, J.; Asare, G.; Yousuf, A.; Medved, M.; Antic, T.; Eggener, S.; Karczmar, G. S.; Oto, A. Quantitative Multi-Parametric MRI of the Prostate Reveals Racial Differences. Preprints 2024, 2024092234. https://doi.org/10.20944/preprints202409.2234.v1

Abstract

This study investigated whether quantitative MRI and histology of the prostate reveals differences between races that can affect diagnosis. Cancer signal enhancement rate (α) on DCE-MRI was significantly higher for African Americans (AA) compared to Caucasian Americans (CA). Signal washout rate (β) was significantly lower in benign tissue in AAs and significantly elevated in cancers in AAs. However, no significant differences were found for ADC and T2. ROC analysis showed that ADC and T2 are slightly less effective in AA compared to CA. DCE significantly improves the differentiation of PCa from benign in AAs (α: 52%, β: 62% more effective in AA compared to CA). Histologic analysis showed cancers have a greater proportion of epithelium and lower lumen in AA compared to CA. This study shows that the different races have different quantitative MRI values and histologic makeup. Quantitative DCE-MRI is highly effective and improves PCa diagnosis in African Americans.

Keywords

prostate cancer; MRI; racial differences; quantitative; DCE-MRI; African Americans; Caucasian Americans

Subject

Medicine and Pharmacology, Other

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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