Version 1
: Received: 26 September 2024 / Approved: 27 September 2024 / Online: 30 September 2024 (13:10:53 CEST)
How to cite:
Alves dos Santos, K.; Alves de Sousa, L. M. C.; de Souza, K. S. C.; Amigo, O. M.; Luchessi, A. D.; Silbiger, V. N. mirSNPs as Potential Colorectal Cancer Biomarkers: A Systematic Review. Preprints2024, 2024092291. https://doi.org/10.20944/preprints202409.2291.v1
Alves dos Santos, K.; Alves de Sousa, L. M. C.; de Souza, K. S. C.; Amigo, O. M.; Luchessi, A. D.; Silbiger, V. N. mirSNPs as Potential Colorectal Cancer Biomarkers: A Systematic Review. Preprints 2024, 2024092291. https://doi.org/10.20944/preprints202409.2291.v1
Alves dos Santos, K.; Alves de Sousa, L. M. C.; de Souza, K. S. C.; Amigo, O. M.; Luchessi, A. D.; Silbiger, V. N. mirSNPs as Potential Colorectal Cancer Biomarkers: A Systematic Review. Preprints2024, 2024092291. https://doi.org/10.20944/preprints202409.2291.v1
APA Style
Alves dos Santos, K., Alves de Sousa, L. M. C., de Souza, K. S. C., Amigo, O. M., Luchessi, A. D., & Silbiger, V. N. (2024). mirSNPs as Potential Colorectal Cancer Biomarkers: A Systematic Review. Preprints. https://doi.org/10.20944/preprints202409.2291.v1
Chicago/Turabian Style
Alves dos Santos, K., André Ducati Luchessi and Vivian Nogueira Silbiger. 2024 "mirSNPs as Potential Colorectal Cancer Biomarkers: A Systematic Review" Preprints. https://doi.org/10.20944/preprints202409.2291.v1
Abstract
Colorectal cancer (CRC) is the third most common neoplasm in the world and the second with the highest mortality rate. Single nucleotide polymorphisms (SNPs) in miRNA genes (mirSNPs) may be related to dysregulated miRNA expression in several neoplasms. This systematic review aims to investigate studies that investigate SNPs located in regions of miRNA genes that influence their expression and are associated with CRC, as well as their potential as biomarkers for the disease, based on the available literature. For this, searches were performed in public databases, including MEDLINE/PubMed, Embase, Web of Science and Scopus. The rigorous review of the PRISMA 2020 guidelines and the methodological quality of the studies were assessed sing the Newcastle-Ottawa scale and the Mixed Methods Assessment Tool. Of the 175 studies identified, 26 were considered eligible: 18 of them highlighted mirSNPs as potential biomarkers of risk and prognosis for CRC; 4 studies suggested a protective role; 1 study linked mirSNPs to treatment; and 3 studies found no relevant evidence. These results highlight the need for further research on this topic, since these variants have the potential to serve as biomarkers and may be useful in assessing risk, prognosis, and developing therapeutic strategies for patients with CRC.
Keywords
miRNA; SNP; MirSNP; colorectal cancer; biomarkers
Subject
Medicine and Pharmacology, Oncology and Oncogenics
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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