PreprintArticleVersion 1This version is not peer-reviewed
The Synergistic Effect of Intradialytic Concurrent Training and Melatonin Supplementation on Oxidative Stress and Inflammation in Hemodialysis Patients: A Double-Blind Randomized Controlled Trial
Version 1
: Received: 29 September 2024 / Approved: 30 September 2024 / Online: 30 September 2024 (13:56:12 CEST)
How to cite:
Marzougui, H.; Ben Dhia, I.; Mezghani, I.; Maaloul, R.; Toumi, S.; Kammoun, K.; Chaabouni, M. N.; Ayadi, F.; Ben Hmida, M.; Turki, M.; Hammouda, O. The Synergistic Effect of Intradialytic Concurrent Training and Melatonin Supplementation on Oxidative Stress and Inflammation in Hemodialysis Patients: A Double-Blind Randomized Controlled Trial. Preprints2024, 2024092408. https://doi.org/10.20944/preprints202409.2408.v1
Marzougui, H.; Ben Dhia, I.; Mezghani, I.; Maaloul, R.; Toumi, S.; Kammoun, K.; Chaabouni, M. N.; Ayadi, F.; Ben Hmida, M.; Turki, M.; Hammouda, O. The Synergistic Effect of Intradialytic Concurrent Training and Melatonin Supplementation on Oxidative Stress and Inflammation in Hemodialysis Patients: A Double-Blind Randomized Controlled Trial. Preprints 2024, 2024092408. https://doi.org/10.20944/preprints202409.2408.v1
Marzougui, H.; Ben Dhia, I.; Mezghani, I.; Maaloul, R.; Toumi, S.; Kammoun, K.; Chaabouni, M. N.; Ayadi, F.; Ben Hmida, M.; Turki, M.; Hammouda, O. The Synergistic Effect of Intradialytic Concurrent Training and Melatonin Supplementation on Oxidative Stress and Inflammation in Hemodialysis Patients: A Double-Blind Randomized Controlled Trial. Preprints2024, 2024092408. https://doi.org/10.20944/preprints202409.2408.v1
APA Style
Marzougui, H., Ben Dhia, I., Mezghani, I., Maaloul, R., Toumi, S., Kammoun, K., Chaabouni, M. N., Ayadi, F., Ben Hmida, M., Turki, M., & Hammouda, O. (2024). The Synergistic Effect of Intradialytic Concurrent Training and Melatonin Supplementation on Oxidative Stress and Inflammation in Hemodialysis Patients: A Double-Blind Randomized Controlled Trial. Preprints. https://doi.org/10.20944/preprints202409.2408.v1
Chicago/Turabian Style
Marzougui, H., Mouna Turki and Omar Hammouda. 2024 "The Synergistic Effect of Intradialytic Concurrent Training and Melatonin Supplementation on Oxidative Stress and Inflammation in Hemodialysis Patients: A Double-Blind Randomized Controlled Trial" Preprints. https://doi.org/10.20944/preprints202409.2408.v1
Abstract
Background: This study aimed to investigate the effects of intradialytic concurrent (resistance-endurance) training combined with melatonin (MEL) supplementation on oxidative stress, inflammation, and cellular damage in hemodialysis (HD) patients. Methods: Thirty-two hemodialysis (HD) patients were randomly assigned to three groups: Exercise (EX)-MEL, EX-Placebo (PLA), and Control (C)-PLA. Participants in the EX-MEL and EX-PLA groups underwent 12 weeks of concurrent training. Before nocturnal sleep, they ingested either 3 mg of MEL (EX-MEL) or a placebo (EX-PLA and C-PLA). Blood samples were collected at baseline and after 12 weeks of intervention to assess lipid peroxidation [malondialdehyde (MDA)], antioxidant biomarkers [ferric reducing antioxidant power (FRAP), reduced glutathione (GSH), total thiol (THIOL)], total bilirubin (TBIL), uric acid (UA), biomarkers of muscle and liver damage [aspartate aminotransferase (ASAT), alanine aminotransferase (ALAT), creatine kinase (CK), lactate dehydrogenase (LDH), Gamma-glutamyltransferase (Gamma-GT)], and inflammation [C-reactive protein (CRP)]. Results: EX-MEL demonstrated a decrease of MDA (p
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
