Version 1
: Received: 30 September 2024 / Approved: 1 October 2024 / Online: 1 October 2024 (05:00:10 CEST)
How to cite:
Gikoska, M.; Gilbert, T.; Wierzbicki, L. A.; Thompson, A. R. Dysbiosis of the Gut Microbiota Being a Contributing Factor to Parkinson’s Disease: A Literature Review. Preprints2024, 2024100016. https://doi.org/10.20944/preprints202410.0016.v1
Gikoska, M.; Gilbert, T.; Wierzbicki, L. A.; Thompson, A. R. Dysbiosis of the Gut Microbiota Being a Contributing Factor to Parkinson’s Disease: A Literature Review. Preprints 2024, 2024100016. https://doi.org/10.20944/preprints202410.0016.v1
Gikoska, M.; Gilbert, T.; Wierzbicki, L. A.; Thompson, A. R. Dysbiosis of the Gut Microbiota Being a Contributing Factor to Parkinson’s Disease: A Literature Review. Preprints2024, 2024100016. https://doi.org/10.20944/preprints202410.0016.v1
APA Style
Gikoska, M., Gilbert, T., Wierzbicki, L. A., & Thompson, A. R. (2024). Dysbiosis of the Gut Microbiota Being a Contributing Factor to Parkinson’s Disease: A Literature Review. Preprints. https://doi.org/10.20944/preprints202410.0016.v1
Chicago/Turabian Style
Gikoska, M., Lucyna A. Wierzbicki and Arabella R. Thompson. 2024 "Dysbiosis of the Gut Microbiota Being a Contributing Factor to Parkinson’s Disease: A Literature Review" Preprints. https://doi.org/10.20944/preprints202410.0016.v1
Abstract
Parkinson’s disease (PD) is a prevalent neurodegenerative disorder characterized by symptoms such as tremors, dementia, and bradykinesia. Early non-motor signs, including constipation and hyposmia, suggest a potential connection between PD and the gut. The loss of dopaminergic neurons in the substantia nigra is a hallmark of PD, with unknown causes. While current treatments provide symptom relief, there are no therapies to slow the progression of the disease. The gut microbiota plays a role in inflammatory and immune responses and has been implicated in neurological disorders. The connection between gut microbiota and neurodegenerative disease remains unclear. In this paper, we aim to explore the potential link between gut microbiome dysbiosis in PD, focusing on constipation, which is an early symptom of the disease. Our review will examine the evidence that suggests the possibility of chronic intestinal inflammation that may contribute to the development of Parkinson’s disease and implicate further connections with other neurodegenerative diseases.
Keywords
Parkinson’s disease; Dopamine; α-Synuclein (αSyn); Gut microbiota; Gut microbiome dysbiosis
Subject
Medicine and Pharmacology, Neuroscience and Neurology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
