Version 1
: Received: 27 September 2024 / Approved: 29 September 2024 / Online: 2 October 2024 (13:49:04 CEST)
How to cite:
Quintana, D. S.; Macías, Y.; Nevado, J.; Spicer, D. E.; Anderson, R. H. The Atrioventricular Conduction Axis in Man and Mouse. Preprints2024, 2024100169. https://doi.org/10.20944/preprints202410.0169.v1
Quintana, D. S.; Macías, Y.; Nevado, J.; Spicer, D. E.; Anderson, R. H. The Atrioventricular Conduction Axis in Man and Mouse. Preprints 2024, 2024100169. https://doi.org/10.20944/preprints202410.0169.v1
Quintana, D. S.; Macías, Y.; Nevado, J.; Spicer, D. E.; Anderson, R. H. The Atrioventricular Conduction Axis in Man and Mouse. Preprints2024, 2024100169. https://doi.org/10.20944/preprints202410.0169.v1
APA Style
Quintana, D. S., Macías, Y., Nevado, J., Spicer, D. E., & Anderson, R. H. (2024). The Atrioventricular Conduction Axis in Man and Mouse. Preprints. https://doi.org/10.20944/preprints202410.0169.v1
Chicago/Turabian Style
Quintana, D. S., Diane E. Spicer and Robert H. Anderson. 2024 "The Atrioventricular Conduction Axis in Man and Mouse" Preprints. https://doi.org/10.20944/preprints202410.0169.v1
Abstract
Those using the mouse for the purposes of electrophysiological research presume that the morphology of the conduction axis is comparable with the human arrangement. As yet, however, to the best of our knowledge, no direct comparison has been made between the species. By comparing our extensive histological findings in the human heart with comparable serially-sectioned datasets prepared from adult murine hearts, we aimed to provide this information. When comparing the gross anatomy, we used three-dimensional datasets of neonatal mice hearts prepared using episcopic microscopy. The overall cardiac architecture is comparable, although the mouse has a persistent left superior caval vein draining via the coronary sinus. An inferior pyramidal space, and an infero-septal recess, are both present in the murine heart, although not as well developed as in the human heart. The overall arrangement of the conduction axis is similarly comparable, albeit with subtle differences reflecting the incomplete wedging of the subaortic outflow tract in the murine heart. Most significantly, the findings in both species reveal the presence of extensive superior septal pathways, which perhaps explain the finding of base-to-apex activation of the ventricular mass known to occur in the murine heart.
Keywords
atrioventricular node; bundle of His; bundle branches; fasciculo-ventricular connections; nodoventricular connections; mahaim conduction; superior septal pathways
Subject
Biology and Life Sciences, Anatomy and Physiology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
