PreprintReviewVersion 1This version is not peer-reviewed
Assessing Mild Traumatic Brain Injury Associated Blood Brain Barrier (BBB) Damage and Restoration Using Late Phase Perfusion Analysis by 3D ASL MRI- Implications for Predicting Progressive Brain Injury
Version 1
: Received: 2 October 2024 / Approved: 3 October 2024 / Online: 4 October 2024 (00:08:46 CEST)
How to cite:
Joseph, C. R. Assessing Mild Traumatic Brain Injury Associated Blood Brain Barrier (BBB) Damage and Restoration Using Late Phase Perfusion Analysis by 3D ASL MRI- Implications for Predicting Progressive Brain Injury. Preprints2024, 2024100282. https://doi.org/10.20944/preprints202410.0282.v1
Joseph, C. R. Assessing Mild Traumatic Brain Injury Associated Blood Brain Barrier (BBB) Damage and Restoration Using Late Phase Perfusion Analysis by 3D ASL MRI- Implications for Predicting Progressive Brain Injury. Preprints 2024, 2024100282. https://doi.org/10.20944/preprints202410.0282.v1
Joseph, C. R. Assessing Mild Traumatic Brain Injury Associated Blood Brain Barrier (BBB) Damage and Restoration Using Late Phase Perfusion Analysis by 3D ASL MRI- Implications for Predicting Progressive Brain Injury. Preprints2024, 2024100282. https://doi.org/10.20944/preprints202410.0282.v1
APA Style
Joseph, C. R. (2024). Assessing Mild Traumatic Brain Injury Associated Blood Brain Barrier (BBB) Damage and Restoration Using Late Phase Perfusion Analysis by 3D ASL MRI- Implications for Predicting Progressive Brain Injury. Preprints. https://doi.org/10.20944/preprints202410.0282.v1
Chicago/Turabian Style
Joseph, C. R. 2024 "Assessing Mild Traumatic Brain Injury Associated Blood Brain Barrier (BBB) Damage and Restoration Using Late Phase Perfusion Analysis by 3D ASL MRI- Implications for Predicting Progressive Brain Injury" Preprints. https://doi.org/10.20944/preprints202410.0282.v1
Abstract
Mild traumatic brain injury mTBI is a common occurrence around the world, associated with a variety of blunt force and torsion injuries affecting all age groups. Most never reach medical attention, and identification of acute injury and later clearance to return to usual activities is relegated to clinical evaluation particularly in sports injuries. Advanced structural imaging is rarely performed due to the usual absence of associated acute anatomic/hemorrhagic changes. This review targets physiologic imaging techniques available to identify subtle blood brain barrier dysfunction and white matter tract shear injury, and their association with chronic traumatic encephalopathy. These techniques provide needed objective measures to assure recovery from injury in those patients with persistent cognitive/emotional symptoms and in the face of repetitive mTBI.
Medicine and Pharmacology, Neuroscience and Neurology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
