Version 1
: Received: 3 October 2024 / Approved: 4 October 2024 / Online: 4 October 2024 (08:46:26 CEST)
How to cite:
Hennings, R.; LeDuc, G.-D.; Tönjes, A.; Lemke, J.; Thiery, J.; Kratzsch, J.; Roth, A. Screening for Hypophosphatasia in Adult Patients at a Maximum Care Provider – Retrospective Analyses over Fifteen Years. Preprints2024, 2024100318. https://doi.org/10.20944/preprints202410.0318.v1
Hennings, R.; LeDuc, G.-D.; Tönjes, A.; Lemke, J.; Thiery, J.; Kratzsch, J.; Roth, A. Screening for Hypophosphatasia in Adult Patients at a Maximum Care Provider – Retrospective Analyses over Fifteen Years. Preprints 2024, 2024100318. https://doi.org/10.20944/preprints202410.0318.v1
Hennings, R.; LeDuc, G.-D.; Tönjes, A.; Lemke, J.; Thiery, J.; Kratzsch, J.; Roth, A. Screening for Hypophosphatasia in Adult Patients at a Maximum Care Provider – Retrospective Analyses over Fifteen Years. Preprints2024, 2024100318. https://doi.org/10.20944/preprints202410.0318.v1
APA Style
Hennings, R., LeDuc, G. D., Tönjes, A., Lemke, J., Thiery, J., Kratzsch, J., & Roth, A. (2024). Screening for Hypophosphatasia in Adult Patients at a Maximum Care Provider – Retrospective Analyses over Fifteen Years. Preprints. https://doi.org/10.20944/preprints202410.0318.v1
Chicago/Turabian Style
Hennings, R., Jürgen Kratzsch and Andreas Roth. 2024 "Screening for Hypophosphatasia in Adult Patients at a Maximum Care Provider – Retrospective Analyses over Fifteen Years" Preprints. https://doi.org/10.20944/preprints202410.0318.v1
Abstract
Introduction: Persistent hypophosphatasia (pHPE) can be an expression of hypophosphatasia (HPP), a rare disorder of bone metabolism resulting from ALPL gene pathogenic variants. The aim of this study was to identify the role of auxiliary general biomarkers to verify low ALP serum activity as an alert parameter for an ALPL gene pathogenic variants.
Material: A retrospective analysis of adult patients with at least one reduced ALP value of less than 21 U/L was performed. 88 patients had a temporary HPE (tHPE group). 12 out of 20 patients with persistent HPE agreed to a genetic analysis. 11 patients had a pathogenic ALPL gene variant (ALPL group). Hemoglobin [HB], alanine aminotransferase [ALT], aspartate aminotransferase [AST], gamma-glutamyl transferase [GGT], calcium, phosphate, thyrotropin [TSH], albumin, total protein, and C-reactive protein [CRP] levels) represented basic biomarkers. A statistical comparison of general biomarkers was performed between both groups.
Results: The mean HB, ALP, AST, calcium, albumin, and total protein levels were lower in the tHPE group (p
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
