THOP1 Is Entailed in a Genetic Fingerprint Associated with Late-Onset Alzheimer’s Disease

Sharlee Climer

doi:10.20944/preprints202410.0335.v1

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preprints.org > biology and life sciences > neuroscience and neurology > doi: 10.20944/preprints202410.0335.v1 (registering DOI)

Preprint Article Version 1 This version is not peer-reviewed

THOP1 Is Entailed in a Genetic Fingerprint Associated with Late-Onset Alzheimer’s Disease

Sharlee Climer

Version 1 : Received: 3 October 2024 / Approved: 4 October 2024 / Online: 4 October 2024 (13:00:38 CEST)

How to cite: Climer, S. THOP1 Is Entailed in a Genetic Fingerprint Associated with Late-Onset Alzheimer’s Disease. Preprints 2024, 2024100335. https://doi.org/10.20944/preprints202410.0335.v1 Climer, S. THOP1 Is Entailed in a Genetic Fingerprint Associated with Late-Onset Alzheimer’s Disease. Preprints 2024, 2024100335. https://doi.org/10.20944/preprints202410.0335.v1

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MDPI and ACS Style

Climer, S. THOP1 Is Entailed in a Genetic Fingerprint Associated with Late-Onset Alzheimer’s Disease. Preprints 2024, 2024100335. https://doi.org/10.20944/preprints202410.0335.v1

APA Style

Climer, S. (2024). THOP1 Is Entailed in a Genetic Fingerprint Associated with Late-Onset Alzheimer’s Disease. Preprints. https://doi.org/10.20944/preprints202410.0335.v1

Chicago/Turabian Style

Climer, S. 2024 "THOP1 Is Entailed in a Genetic Fingerprint Associated with Late-Onset Alzheimer’s Disease" Preprints. https://doi.org/10.20944/preprints202410.0335.v1

Abstract

In a systematic explorative study of genetic patterns on chromosome 19, we discovered a pattern comprised of 23 SNP alleles that is significantly associated with late-onset Alzheimer’s disease (AD). This association is validated using two independent data sets. The pattern includes THOP1, which has a long and disputatious relationship with AD. It also spans SLC39A3 and SGTA and is upstream from DIRAS1. We utilized population data to observe the frequencies of this genetic pattern for 11 different ancestries and note that it is highly common for Europeans and relatively infrequent for Africans. This research provides a distinct genetic signature for AD risk as well as insights into the complicated relationship between this disease and THOP1.

Keywords

THOP1; Alzheimer’s disease; genetic risk factor; haplotype; BlocBuster

Subject

Biology and Life Sciences, Neuroscience and Neurology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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