Preprint Case Report Version 1 This version is not peer-reviewed

Visceral Perforation Complicating BRAF/MEK Targeted Therapy of Papillary Thyroid Carcinoma with Anaplastic Areas

Simon Louis Barry
* ,
Emer Lynch
,
Philip Bredin
,
Sebastian McWilliams
,
Julie McCarthy
,
Orla O'Mahony
,
Linda Feeley
,
Killian Nugent
,
Patrick Sheahan
,
Deirdre O'Hanlon
,
David O’Reilly
,
Seamus O'Reilly
Version 1 : Received: 3 October 2024 / Approved: 4 October 2024 / Online: 4 October 2024 (12:59:50 CEST)

How to cite: Barry, S. L.; Lynch, E.; Bredin, P.; McWilliams, S.; McCarthy, J.; O'Mahony, O.; Feeley, L.; Nugent, K.; Sheahan, P.; O'Hanlon, D.; O’Reilly, D.; O'Reilly, S. Visceral Perforation Complicating BRAF/MEK Targeted Therapy of Papillary Thyroid Carcinoma with Anaplastic Areas. Preprints 2024, 2024100336. https://doi.org/10.20944/preprints202410.0336.v1 Barry, S. L.; Lynch, E.; Bredin, P.; McWilliams, S.; McCarthy, J.; O'Mahony, O.; Feeley, L.; Nugent, K.; Sheahan, P.; O'Hanlon, D.; O’Reilly, D.; O'Reilly, S. Visceral Perforation Complicating BRAF/MEK Targeted Therapy of Papillary Thyroid Carcinoma with Anaplastic Areas. Preprints 2024, 2024100336. https://doi.org/10.20944/preprints202410.0336.v1

Abstract

Anaplastic thyroid cancer (ATC) is considered to be one of the most virulent, treatment refractory, malignancies. Recent molecular insights into the biology of thyroid cancer have transformed ATC management and BRAF/MEK targeted therapy is now incorporated into guideline based multidisciplinary care. We report visceral perforation in the setting of an extreme response to such therapy in a patient with a mixed papillary thyroid carcinoma and ATC. Molecularly targeted therapy afforded a dramatic, but life-threatening, response to treatment. This report highlights the complexities of care for the patient and treating clinicians.

Keywords

Anaplastic thyroid carcinoma; papillary thyroid carcinoma; targeted therapy; perforation; complications

Subject

Medicine and Pharmacology, Oncology and Oncogenics

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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