Version 1
: Received: 4 October 2024 / Approved: 4 October 2024 / Online: 4 October 2024 (15:43:32 CEST)
How to cite:
Salagean, A. A.; Moldovan, C. A.-D.; Slevin, M. Unique Properties of Naked Mole Rat Hyaluronan— Potential Utilization in Management of Glioblastoma. Preprints2024, 2024100357. https://doi.org/10.20944/preprints202410.0357.v1
Salagean, A. A.; Moldovan, C. A.-D.; Slevin, M. Unique Properties of Naked Mole Rat Hyaluronan— Potential Utilization in Management of Glioblastoma. Preprints 2024, 2024100357. https://doi.org/10.20944/preprints202410.0357.v1
Salagean, A. A.; Moldovan, C. A.-D.; Slevin, M. Unique Properties of Naked Mole Rat Hyaluronan— Potential Utilization in Management of Glioblastoma. Preprints2024, 2024100357. https://doi.org/10.20944/preprints202410.0357.v1
APA Style
Salagean, A. A., Moldovan, C. A. D., & Slevin, M. (2024). Unique Properties of Naked Mole Rat Hyaluronan— Potential Utilization in Management of Glioblastoma. Preprints. https://doi.org/10.20944/preprints202410.0357.v1
Chicago/Turabian Style
Salagean, A. A., Cezara Anca-Denisa Moldovan and Mark Slevin. 2024 "Unique Properties of Naked Mole Rat Hyaluronan— Potential Utilization in Management of Glioblastoma" Preprints. https://doi.org/10.20944/preprints202410.0357.v1
Abstract
Hyaluronan has been considered in recent years as a potential naturally occurring modifiable scaffold that has the capability to absorb and release drugs over an extended period of time making it suitable as a chemotherapeutic delivery agent. Considering the limited treatment options available in the treatment of glioblastoma, in this review, we discuss the novel utilization of ultra high molecular weight hyaluronan - originally identified as a mechanism for maintaining longevity in the naked mole rat, as both a protective and extracellular matrix optimising scaffold, and a means to deliver therapy in resected brain tumors. The unique properties of this unique form of hyaluronan indicate potential future use in the prevention and treatment of both proliferative based and inflammation driven disease.
Keywords
naked mole rat; hyaluronan; glioblastoma; targeted drug delivery
Subject
Medicine and Pharmacology, Neuroscience and Neurology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
