Version 1
: Received: 4 October 2024 / Approved: 4 October 2024 / Online: 7 October 2024 (11:09:58 CEST)
How to cite:
Baran, H.; Pietryja, M. J.; Kepplinger, B. Importance of Modulating Kynurenine Metabolism—Approaches for the Treatment of Dementia. Preprints2024, 2024100362. https://doi.org/10.20944/preprints202410.0362.v1
Baran, H.; Pietryja, M. J.; Kepplinger, B. Importance of Modulating Kynurenine Metabolism—Approaches for the Treatment of Dementia. Preprints 2024, 2024100362. https://doi.org/10.20944/preprints202410.0362.v1
Baran, H.; Pietryja, M. J.; Kepplinger, B. Importance of Modulating Kynurenine Metabolism—Approaches for the Treatment of Dementia. Preprints2024, 2024100362. https://doi.org/10.20944/preprints202410.0362.v1
APA Style
Baran, H., Pietryja, M. J., & Kepplinger, B. (2024). Importance of Modulating Kynurenine Metabolism—Approaches for the Treatment of Dementia. Preprints. https://doi.org/10.20944/preprints202410.0362.v1
Chicago/Turabian Style
Baran, H., Marcelin Jan Pietryja and Berthold Kepplinger. 2024 "Importance of Modulating Kynurenine Metabolism—Approaches for the Treatment of Dementia" Preprints. https://doi.org/10.20944/preprints202410.0362.v1
Abstract
In this article we focus on kynurenic acid metabolism, a biochemical part of L-tryptophan catabolism, in processes related to memory and cognitive impairment and its subsequent relevance to neuropsychiatric disorders and the ageing process. Kynurenic acid is synthesised from L-kynurenine by kynurenine aminotransferases.Experimental pharmacological studies have shown that elevated levels of kynurenic acid in the brain are associated with impaired learning and that lowering kynurenic acid levels can improve these symptoms. The discovery of new compounds with the ability to block kynurenine aminotransferase opens up new therapeutic avenues against memory impairment and dementia. The newly developed Helix pomatia snail model of memory is being used for this pharmacological approach. In conclusion, diet, exercise and physical activity have a significant impact on the endogenous pharmacology of kynurenic acid and significantly modulate steady-state conditions and delay the events of the ageing process.
Biology and Life Sciences, Neuroscience and Neurology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
