Version 1
: Received: 6 October 2024 / Approved: 7 October 2024 / Online: 7 October 2024 (11:31:15 CEST)
How to cite:
Emmanouilidou, A.; Karanikas, M.; Pazaitou-Panayiotou, K.; Michalopoulos, N. Thyroid Gland Diffuse Lipomatosis: A Case Study and Comprehensive Literature Review. Preprints2024, 2024100385. https://doi.org/10.20944/preprints202410.0385.v1
Emmanouilidou, A.; Karanikas, M.; Pazaitou-Panayiotou, K.; Michalopoulos, N. Thyroid Gland Diffuse Lipomatosis: A Case Study and Comprehensive Literature Review. Preprints 2024, 2024100385. https://doi.org/10.20944/preprints202410.0385.v1
Emmanouilidou, A.; Karanikas, M.; Pazaitou-Panayiotou, K.; Michalopoulos, N. Thyroid Gland Diffuse Lipomatosis: A Case Study and Comprehensive Literature Review. Preprints2024, 2024100385. https://doi.org/10.20944/preprints202410.0385.v1
APA Style
Emmanouilidou, A., Karanikas, M., Pazaitou-Panayiotou, K., & Michalopoulos, N. (2024). Thyroid Gland Diffuse Lipomatosis: A Case Study and Comprehensive Literature Review. Preprints. https://doi.org/10.20944/preprints202410.0385.v1
Chicago/Turabian Style
Emmanouilidou, A., Kalliopi Pazaitou-Panayiotou and Nickos Michalopoulos. 2024 "Thyroid Gland Diffuse Lipomatosis: A Case Study and Comprehensive Literature Review" Preprints. https://doi.org/10.20944/preprints202410.0385.v1
Abstract
Diffuse lipomatosis of the thyroid (DLT) is a rare condition characterized by the infiltration of thyroid parenchyma with mature adipose cells, replacing normal follicular structure. Though uncommon, it often presents as neck swelling or compression symptoms such as dyspnea, dysphagia, and hoarseness, complicating diagnosis. This case study details a 61-year-old female patient with DLT, who presented with a multinodular goiter and progressive neck swelling, and reviews 53 additional cases from the literature. The review reveals that DLT is often misdiagnosed due to its overlapping features with other thyroid pathologies. The exact pathophysiological mechanism remains unclear, but hypotheses include tissue hypoxia, embryological malformations, or lipid metabolism disturbances. Surgical excision is the most common treatment, particularly for symptomatic patients, yielding positive long-term results. Future research should focus on clarifying DLT’s exact etiology and improving diagnostic accuracy, especially in differentiating it from other fat-infiltrated thyroid lesions such as amyloid goiter and adenolipomas. Enhanced understanding will guide better management strategies and improve patient outcomes in this rare yet significant thyroid disorder.
Keywords
diffuse lipomatosis; thyroid; amyloid goiter; case report; review
Subject
Medicine and Pharmacology, Clinical Medicine
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
