Version 1
: Received: 5 October 2024 / Approved: 7 October 2024 / Online: 7 October 2024 (12:13:18 CEST)
How to cite:
Trautwein, I.; Behme, D.; Kunkel, P.; Gerdes, J.; Mohnike, K. Anatomical Characteristics of Cervicomedullary Compression on MRI Scans in Children with Achondroplasia. Preprints2024, 2024100453. https://doi.org/10.20944/preprints202410.0453.v1
Trautwein, I.; Behme, D.; Kunkel, P.; Gerdes, J.; Mohnike, K. Anatomical Characteristics of Cervicomedullary Compression on MRI Scans in Children with Achondroplasia. Preprints 2024, 2024100453. https://doi.org/10.20944/preprints202410.0453.v1
Trautwein, I.; Behme, D.; Kunkel, P.; Gerdes, J.; Mohnike, K. Anatomical Characteristics of Cervicomedullary Compression on MRI Scans in Children with Achondroplasia. Preprints2024, 2024100453. https://doi.org/10.20944/preprints202410.0453.v1
APA Style
Trautwein, I., Behme, D., Kunkel, P., Gerdes, J., & Mohnike, K. (2024). Anatomical Characteristics of Cervicomedullary Compression on MRI Scans in Children with Achondroplasia. Preprints. https://doi.org/10.20944/preprints202410.0453.v1
Chicago/Turabian Style
Trautwein, I., Jasper Gerdes and Klaus Mohnike. 2024 "Anatomical Characteristics of Cervicomedullary Compression on MRI Scans in Children with Achondroplasia" Preprints. https://doi.org/10.20944/preprints202410.0453.v1
Abstract
This retrospective study assessed anatomical characteristics of cervicomedullary compression in children with achondroplasia. Twelve anatomical parameters were analyzed (foramen magnum diameter and area; myelon area; clivus length; tentorium and occipital angles; brainstem volume outside the posterior fossa; and posterior fossa, cerebellum, supratentorial ventricular system, intracranial cerebrospinal fluid, and fourth ventricle volumes) from sagittal and transversal T1- and T2-weighted magnetic resonance imaging (MRI) scans from 37 children with achondroplasia aged ≤ 4 years (median [range] 0.8 [0.1–3.6] years) and compared with scans from 37 children without achondroplasia (median age 1.5 [0–3.9] years). Mann-Whitney U testing was used for between-group comparisons. Foramen magnum diameter and area were significantly smaller in children with achondroplasia compared with the reference group (mean 10.0 vs. 16.1 mm [p < 0.001] and 109.0 vs. 160.8 mm2 [p = 0.005], respectively). The tentorial angle was also steeper in children with achondroplasia (mean 47.6 vs. 38.1 degrees; p < 0.001), while the clivus was significantly shorter (mean 23.5 vs. 30.3 mm; p < 0.001). Significant differences were also observed in myelon area, occipital angle, fourth ventricle, intracranial cerebrospinal fluid and supratentorial ventricular volumes, and the volume of brainstem protruding beyond the posterior fossa (all p < 0.05). MRI analysis of brain structures may provide a standardized value to indicate decompression surgery in children with achondroplasia.
Keywords
achondroplasia; magnetic resonance imaging; cervicomedullary compression; foramen magnum stenosis; decompression surgery
Subject
Medicine and Pharmacology, Pediatrics, Perinatology and Child Health
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
