Version 1
: Received: 4 October 2024 / Approved: 7 October 2024 / Online: 8 October 2024 (09:40:50 CEST)
How to cite:
Song, Y.; Wang, S.; Xu, Y. Mirror-Image RNA: A Right-Handed Z-Form RNA and Its Ligand Complex. Preprints2024, 2024100457. https://doi.org/10.20944/preprints202410.0457.v1
Song, Y.; Wang, S.; Xu, Y. Mirror-Image RNA: A Right-Handed Z-Form RNA and Its Ligand Complex. Preprints 2024, 2024100457. https://doi.org/10.20944/preprints202410.0457.v1
Song, Y.; Wang, S.; Xu, Y. Mirror-Image RNA: A Right-Handed Z-Form RNA and Its Ligand Complex. Preprints2024, 2024100457. https://doi.org/10.20944/preprints202410.0457.v1
APA Style
Song, Y., Wang, S., & Xu, Y. (2024). Mirror-Image RNA: A Right-Handed Z-Form RNA and Its Ligand Complex. Preprints. https://doi.org/10.20944/preprints202410.0457.v1
Chicago/Turabian Style
Song, Y., Shiyu Wang and Yan Xu. 2024 "Mirror-Image RNA: A Right-Handed Z-Form RNA and Its Ligand Complex" Preprints. https://doi.org/10.20944/preprints202410.0457.v1
Abstract
Until now, Z-form RNAs were believed to only adopt a left-handed double helix structure. In this study, we describe the first observation of a right-handed Z-form RNA in NMR solution formed by L-nucleic acid RNA and present the first resolution structure of the complex between a right-handed Z-form RNA and a curaxin ligand. This newly described topology is of great interest as it shows that Z-form RNAs can also adopt a right-handed double helix structure and interact with ligand molecules. The structural information provides a platform for the design of topology specific Z-form-targeting compounds and is valuable for the development of new potent anticancer drugs.
Biology and Life Sciences, Biochemistry and Molecular Biology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
