Version 1
: Received: 6 October 2024 / Approved: 7 October 2024 / Online: 8 October 2024 (08:36:51 CEST)
How to cite:
Papoutsoglou, P.; Morillon, A. Extracellular Vesicle lncRNA Are Key Biomolecules for Cell-to-Cell Communication and Circulating Cancer Biomarkers. Preprints2024, 2024100469. https://doi.org/10.20944/preprints202410.0469.v1
Papoutsoglou, P.; Morillon, A. Extracellular Vesicle lncRNA Are Key Biomolecules for Cell-to-Cell Communication and Circulating Cancer Biomarkers. Preprints 2024, 2024100469. https://doi.org/10.20944/preprints202410.0469.v1
Papoutsoglou, P.; Morillon, A. Extracellular Vesicle lncRNA Are Key Biomolecules for Cell-to-Cell Communication and Circulating Cancer Biomarkers. Preprints2024, 2024100469. https://doi.org/10.20944/preprints202410.0469.v1
APA Style
Papoutsoglou, P., & Morillon, A. (2024). Extracellular Vesicle lncRNA Are Key Biomolecules for Cell-to-Cell Communication and Circulating Cancer Biomarkers. Preprints. https://doi.org/10.20944/preprints202410.0469.v1
Chicago/Turabian Style
Papoutsoglou, P. and Antonin Morillon. 2024 "Extracellular Vesicle lncRNA Are Key Biomolecules for Cell-to-Cell Communication and Circulating Cancer Biomarkers" Preprints. https://doi.org/10.20944/preprints202410.0469.v1
Abstract
Extracellular vesicles (EVs) are secreted by almost every cell type and are considered as carriers of active biomolecules, such as nucleic acids, proteins and lipids. Their content can be up-taken and released into the cytoplasm of recipient cells, thereby inducing gene reprogramming and phenotypic changes in the acceptor cells. Whether the effects of EVs on the physiology of recipient cells are mediated by individual biomolecules or it is the collective outcome of the total transferred EV content, is still under debate. The EV RNA content consists of several types of RNA, such as messenger RNA (mRNA), microRNA (miRNA) and long non-coding RNA (lncRNA), the latter defined as transcripts longer than 200 nucleotides, that do not code for proteins, but with important established biological functions. This review aims to update our insights on the functional roles of EV and their cargo non-coding RNA during cancer progression, to highlight the utility of EV RNA as novel diagnostic or prognostic biomarkers in cancer, and to tackle the technological advances and limitations for EV RNA identification, integrity assessment and preservation of its functionality.
Biology and Life Sciences, Biochemistry and Molecular Biology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
