Version 1
: Received: 7 October 2024 / Approved: 7 October 2024 / Online: 8 October 2024 (08:56:24 CEST)
How to cite:
Jelonek, K.; Musiał-Kulik, M.; Pastusiak, M.; Foryś, A.; Zięba, A.; Kasperczyk, J. Nanoparticles as Potential Delivery System of Phenothiazine Derivatives for Anticancer Application. Preprints2024, 2024100517. https://doi.org/10.20944/preprints202410.0517.v1
Jelonek, K.; Musiał-Kulik, M.; Pastusiak, M.; Foryś, A.; Zięba, A.; Kasperczyk, J. Nanoparticles as Potential Delivery System of Phenothiazine Derivatives for Anticancer Application. Preprints 2024, 2024100517. https://doi.org/10.20944/preprints202410.0517.v1
Jelonek, K.; Musiał-Kulik, M.; Pastusiak, M.; Foryś, A.; Zięba, A.; Kasperczyk, J. Nanoparticles as Potential Delivery System of Phenothiazine Derivatives for Anticancer Application. Preprints2024, 2024100517. https://doi.org/10.20944/preprints202410.0517.v1
APA Style
Jelonek, K., Musiał-Kulik, M., Pastusiak, M., Foryś, A., Zięba, A., & Kasperczyk, J. (2024). Nanoparticles as Potential Delivery System of Phenothiazine Derivatives for Anticancer Application. Preprints. https://doi.org/10.20944/preprints202410.0517.v1
Chicago/Turabian Style
Jelonek, K., Andrzej Zięba and Janusz Kasperczyk. 2024 "Nanoparticles as Potential Delivery System of Phenothiazine Derivatives for Anticancer Application" Preprints. https://doi.org/10.20944/preprints202410.0517.v1
Abstract
Cancer remains a one of a leading cause of death worldwide, and thus there is a need for the de-velopment of innovative and more effective treatment strategies. The aim of the study was to evaluate two types of nanoparticles – nanospheres and micelles obtained from PLA-based pol-ymers for discovering their potential for delivery of four types of phenothiazine derivatives. The morphology, drug loading properties, cytocompatibility, hemolytic properties and anti-cancer activity has been analyzed. The micelles exhibited significantly higher drug loading properties, release process and cytotoxic activity against cancer cells compared to the nano-spheres. The micelles containing 5-methyl-12H-quino[3,4-b][1,4]benzothiazinium chloride with OH group as substituent in 10-position of the quinobenzothiazine ring showed the highest drug loading content, the most efficient drug release, the lowest hemolytic activity and the most sig-nificant cytotoxic effect against HeLa cells. The conducted study enabled to develop delivery system for the new anticancer compound and showed that the choice of drug carrier has a crucial effect on its cytotoxic potential against cancer cells.
Keywords
phenothiazine; phenothiazine derivatives; drug delivery system; nanoparticles; nanocarriers; anticancer drugs
Subject
Medicine and Pharmacology, Pharmacy
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
