Version 1
: Received: 8 October 2024 / Approved: 8 October 2024 / Online: 8 October 2024 (17:03:35 CEST)
How to cite:
Keremidarska-Markova, M.; Sazdova, I.; Mladenov, M.; Pilicheva, B.; Zagorchev, P.; Gagov, H. Sirtuin 1 and Hormonal Regulations in Aging. Preprints2024, 2024100607. https://doi.org/10.20944/preprints202410.0607.v1
Keremidarska-Markova, M.; Sazdova, I.; Mladenov, M.; Pilicheva, B.; Zagorchev, P.; Gagov, H. Sirtuin 1 and Hormonal Regulations in Aging. Preprints 2024, 2024100607. https://doi.org/10.20944/preprints202410.0607.v1
Keremidarska-Markova, M.; Sazdova, I.; Mladenov, M.; Pilicheva, B.; Zagorchev, P.; Gagov, H. Sirtuin 1 and Hormonal Regulations in Aging. Preprints2024, 2024100607. https://doi.org/10.20944/preprints202410.0607.v1
APA Style
Keremidarska-Markova, M., Sazdova, I., Mladenov, M., Pilicheva, B., Zagorchev, P., & Gagov, H. (2024). Sirtuin 1 and Hormonal Regulations in Aging. Preprints. https://doi.org/10.20944/preprints202410.0607.v1
Chicago/Turabian Style
Keremidarska-Markova, M., Plamen Zagorchev and Hristo Gagov. 2024 "Sirtuin 1 and Hormonal Regulations in Aging" Preprints. https://doi.org/10.20944/preprints202410.0607.v1
Abstract
Aging affects structure and functions of all organs and systems in the organism. Significant changes in the hormonal levels are registered in elderly individuals. They often become a predisposition for chronic diseases, including cardiovascular, neurodegenerative, and metabolic disorders. Therefore, immense scientific efforts are concentrated in the investigation of molecular mechanisms and drugs with potential to diminish the senescent hormonal changes. Sirtuin 1 (SIRT1), a member of the sirtuin deacetylases family, has been extensively studied as regulator of multiple pathways related to antioxidant properties, optimal immune response and metabolism. SIRT1 plays a crucial role in regulating various hormonal pathways and maintaining homeostasis. In the present work we review the interplay between SIRT1 and hormonal regulations, including endocrine role of the hypothalamic-pituitary-thyroid, -adrenal, -gonadal, and -liver axes, of other endocrine glands and of non-endocrine tissues in aging body. The application of natural SIRT1 activators, such as resveratrol, curcumin, paeonol, and Buyang Huanwu Decoction, for treatment of senescence and aging is discussed. SIRT1 activators improve mitochondrial function, reduce oxidative stress, and promote longevity but their clinical application is limited by low bioavailability and poor permeability across biological barriers. For this reason, advanced delivery strategies, including nose-to-brain drug delivery and nanotechnology-based formulations, are reviewed.
Keywords
Senescence; Sirtuins; Endocrine; Hormone; Bioavailability; Drug delivery
Subject
Biology and Life Sciences, Aging
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
