Characterizing Bloodstream Infections in Chronic Hemodialysis Patients: A Single Center Experience

Mohan Bilikallahalli Sannathimmappa; Rajeev Aravindakshan; Vinod Nambiar; Walaa Abdelmoeiz Ahmed; Layan Salim Al Mazroey; Amjad Mohammed Al-Gazali; Alrayan Hamood Alhooti; Arwa Basim Alhasani; Hind Yousuf Abdullah Al Blushi; Elham Said Ahmed AL Risi; Salima Al Maqbali

doi:10.20944/preprints202410.0971.v1

Submit preprint
How it Works
Instructions for Authors
Subject Areas
Advisory Board
screening preprints
About
Awards
Log in/Register

Instructions for Authors
Awards
About
FAQ
Submit Log in/Register

Share this article with

Create alert

Email:

Load new image

preprints.org > public health and healthcare > public health and health services > doi: 10.20944/preprints202410.0971.v1

Preprint Article Version 1 This version is not peer-reviewed

Characterizing Bloodstream Infections in Chronic Hemodialysis Patients: A Single Center Experience

Mohan Bilikallahalli Sannathimmappa

^* ,

Rajeev Aravindakshan

Vinod Nambiar

Walaa Abdelmoeiz Ahmed

Layan Salim Al Mazroey

Amjad Mohammed Al-Gazali

Alrayan Hamood Alhooti

Arwa Basim Alhasani

Hind Yousuf Abdullah Al Blushi

Elham Said Ahmed AL Risi

Salima Al Maqbali

Version 1 : Received: 11 October 2024 / Approved: 12 October 2024 / Online: 15 October 2024 (03:33:43 CEST)

How to cite: Sannathimmappa, M. B.; Aravindakshan, R.; Nambiar, V.; Ahmed, W. A.; Al Mazroey, L. S.; Al-Gazali, A. M.; Alhooti, A. H.; Alhasani, A. B.; Al Blushi, H. Y. A.; Risi, E. S. A. A.; Al Maqbali, S. Characterizing Bloodstream Infections in Chronic Hemodialysis Patients: A Single Center Experience. Preprints 2024, 2024100971. https://doi.org/10.20944/preprints202410.0971.v1 Sannathimmappa, M. B.; Aravindakshan, R.; Nambiar, V.; Ahmed, W. A.; Al Mazroey, L. S.; Al-Gazali, A. M.; Alhooti, A. H.; Alhasani, A. B.; Al Blushi, H. Y. A.; Risi, E. S. A. A.; Al Maqbali, S. Characterizing Bloodstream Infections in Chronic Hemodialysis Patients: A Single Center Experience. Preprints 2024, 2024100971. https://doi.org/10.20944/preprints202410.0971.v1

Cite

Export citation file: Bib TeX | RIS

MDPI and ACS Style

Sannathimmappa, M. B.; Aravindakshan, R.; Nambiar, V.; Ahmed, W. A.; Al Mazroey, L. S.; Al-Gazali, A. M.; Alhooti, A. H.; Alhasani, A. B.; Al Blushi, H. Y. A.; Risi, E. S. A. A.; Al Maqbali, S. Characterizing Bloodstream Infections in Chronic Hemodialysis Patients: A Single Center Experience. Preprints 2024, 2024100971. https://doi.org/10.20944/preprints202410.0971.v1

APA Style

Sannathimmappa, M. B., Aravindakshan, R., Nambiar, V., Ahmed, W. A., Al Mazroey, L. S., Al-Gazali, A. M., Alhooti, A. H., Alhasani, A. B., Al Blushi, H. Y. A., Risi, E. S. A. A., & Al Maqbali, S. (2024). Characterizing Bloodstream Infections in Chronic Hemodialysis Patients: A Single Center Experience. Preprints. https://doi.org/10.20944/preprints202410.0971.v1

Chicago/Turabian Style

Sannathimmappa, M. B., Elham Said Ahmed AL Risi and Salima Al Maqbali. 2024 "Characterizing Bloodstream Infections in Chronic Hemodialysis Patients: A Single Center Experience" Preprints. https://doi.org/10.20944/preprints202410.0971.v1

Abstract

Background: Bloodstream infections (BSIs) pose a major health risk to hemodialysis patients, significantly contributing to morbidity and mortality. This study aimed to identify the bacterial pathogens responsible for BSIs in this population, analyze clinical and laboratory profiles, and identify risk factors associated with poor outcomes. Methods: This retrospective study was conducted at Sohar Hospital, Oman, analyzing cases from January 2018 to December 2022. Data were obtained from e-health records, focusing on patient demographics, bacterial etiology, antibiotic susceptibility, and clinical outcomes. Statistical analysis included t-tests, Mann-Whitney tests, chi-square, and Fisher’s exact tests, with univariate odds ratios calculated for mortality associations using the R package GTSUMMARY. Results: Among 1332 hemodialysis patients, 148 (11.1%) developed a BSI, with an average age of 60.43±14.46 years. Infections were more common among females (54%) and those over 60 years. The predominant comorbidities were hypertension (86%) and diabetes mellitus (74%). The main causative agents were coagulase-negative staphylococci (29.7%), Staphylococcus aureus (20.3%), Pseudomonas aeruginosa (12.2%), and Klebsiella pneumoniae (8.8%). Gram-negative bacteria showed high susceptibility (80-100%) to carbapenems and piperacillin-tazobactam, while Gram-positive bacteria exhibited 80-100% susceptibility to amoxicillin-clavulanic acid and universal sensitivity to linezolid and vancomycin. Conclusions: BSIs in hemodialysis patients at Sohar Hospital are associated with high morbidity and mortality rates, underscoring the need for prompt empirical antibiotic therapy and targeted treatment adjustments based on culture results. This study highlights critical mortality-associated factors, offering valuable insights for improving patient management and survival outcomes in this vulnerable population.

Keywords

C-reactive protein; End organ dysfunction; Hemodialysis; Lactate; Sepsis; Central Venous Catheter; Hemodialysis; Multidrug Resistance; Sepsis; Staphylococcus

Subject

Public Health and Healthcare, Public Health and Health Services

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Download PDF

Comments (0)

Not displayed online.

Importance: How significant is the paper to the field?

Outstanding/highlight paper

Significant contribution

Incremental contribution

No contribution

I am not qualified to judge

Soundness of evidence/arguments presented:

Conclusions well supported

Most conclusions supported (minor revision needed)

Incomplete evidence (major revision needed)

Hypothesis, unsupported conclusions, or proof-of-principle

I am not qualified to judge

Please leave your comment to this article below.

Mathematical equations can be typed in either LaTeX formats \\[ ... \\] or $$ ... $$, or MathML format <math> ... </math>. Try the LaTeX or MathML example.

Type equation:

Preview:

Copy equation into message below

Close menu

Please click a symbol to insert it into the message box below:

Please enter the link here:

Please enter a valid URL

Optionally, you can enter text that should appear as linked text:

Copy link into message below

Close menu

Please enter or paste the URL to the image here (please only use links to jpg/jpeg, png and gif images):

Please enter a valid URL

Copy image into message below

Close menu

Type author name or keywords to filter the list of references in this group (you can add a new citation under Bibliography):

No existing citations in Discussion Group

Wikify editor is a simple editor for wiki-style mark-up. It was written by MDPI for Sciforum in 2014. The rendering of the mark-up is based on Wiky.php with some tweaks. Rendering of mathematical equations is done with MathJax. Please send us a message for support or for reporting bugs.

Close menu

Please declare any conflicts of interest you may have with this paper, financial or otherwise.

I do not have a conflict of interest

I would like to declare a conflict of interest

Display my name on the website Send my name and email address to the authors

Captcha

Renew

I accept the following conditions:

Comments must follow the standards of professional discourse and should focus on the scientific content of the article. Insulting or offensive language, personal attacks and off-topic remarks will not be permitted. Comments must be written in English. Preprints reserves the right to remove comments without notice. Readers who post comments are obliged to declare any competing interests, financial or otherwise.

We encourage comments and feedback from a broad range of readers. See criteria for comments and our Diversity statement.

Leave a public comment
Send a private comment to the author(s)

* All users must log in before leaving a comment

what’s this?

Add a record of this review to Publons to track and showcase your reviewing expertise across the world’s journals.

Downloads 0

Comments 0

Get PDF Cite Share 0

Bookmark BibSonomy Mendeley Reddit Delicious

Alerts

Notify me about updates to this article or when a peer-reviewed version is published.

Preprints.org is a free preprint server subsidized by MDPI in Basel, Switzerland.

MDPI Initiatives

SciProfiles
Sciforum
Encyclopedia
MDPI Books
Scilit
Proceedings
JAMS

Important links

How it Works
Advisory Board
FAQ
Friendly Journals
Instructions for Authors
About
Statistics

Choose the area that interest you and we will send you notifications of new preprints at your preferred frequency.

Disclaimer

We use cookies on our website to ensure you get the best experience.
Read more about our cookies here.

RSS feed for

Preprints: The Multidisciplinary Preprint Platform

Paste the URL in your RSS reader:

https://www.preprints.org/rss

If you want to subscribe our website in subject-wide, you could find the URL by choosing in the following:

https://www.preprints.org/rss

Please note that by using ScienceDirect RSS feeds, you agree to our Terms of Use and Privacy Policy.