Version 1
: Received: 11 October 2024 / Approved: 12 October 2024 / Online: 13 October 2024 (05:16:55 CEST)
How to cite:
Watanabe, S.; Ueda, M.; Asayama, S. Inhibition of Aβ Aggregation by Cholesterol-End-Modified PEGs Vesicle and Micelle. Preprints2024, 2024100979. https://doi.org/10.20944/preprints202410.0979.v1
Watanabe, S.; Ueda, M.; Asayama, S. Inhibition of Aβ Aggregation by Cholesterol-End-Modified PEGs Vesicle and Micelle. Preprints 2024, 2024100979. https://doi.org/10.20944/preprints202410.0979.v1
Watanabe, S.; Ueda, M.; Asayama, S. Inhibition of Aβ Aggregation by Cholesterol-End-Modified PEGs Vesicle and Micelle. Preprints2024, 2024100979. https://doi.org/10.20944/preprints202410.0979.v1
APA Style
Watanabe, S., Ueda, M., & Asayama, S. (2024). Inhibition of Aβ Aggregation by Cholesterol-End-Modified PEGs Vesicle and Micelle. Preprints. https://doi.org/10.20944/preprints202410.0979.v1
Chicago/Turabian Style
Watanabe, S., Motoki Ueda and Shoichiro Asayama. 2024 "Inhibition of Aβ Aggregation by Cholesterol-End-Modified PEGs Vesicle and Micelle" Preprints. https://doi.org/10.20944/preprints202410.0979.v1
Abstract
We evaluated the inhibitory effects of our developed Chol-PEG2000 micelles and Chol-PEG500 vesicles on amyloid-β (Aβ) aggregation, a key factor in Alzheimer's disease. ThT assay proved that Chol-PEG2000 delayed Aβ fibril elongation by 17 hours and Chol-PEG500 by 40 hours at 10-times molar ratio against Aβ40 peptide. At 50-times molar ratio, both Chol-PEG2000 and Chol-PEG500 significantly inhibited Aβ aggregation, as shown by minimal fluorescence intensity increase over 48 hours.
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
