Version 1
: Received: 11 October 2024 / Approved: 14 October 2024 / Online: 15 October 2024 (11:46:50 CEST)
How to cite:
Chang, H.; Tao, K.; Huang, H.; Jia, J.; Khan, S. N.; Cui, J. Discovery of A Novel Cyclopeptide as Tyrosinase Inhibitor for Skin Lightening. Preprints2024, 2024101006. https://doi.org/10.20944/preprints202410.1006.v1
Chang, H.; Tao, K.; Huang, H.; Jia, J.; Khan, S. N.; Cui, J. Discovery of A Novel Cyclopeptide as Tyrosinase Inhibitor for Skin Lightening. Preprints 2024, 2024101006. https://doi.org/10.20944/preprints202410.1006.v1
Chang, H.; Tao, K.; Huang, H.; Jia, J.; Khan, S. N.; Cui, J. Discovery of A Novel Cyclopeptide as Tyrosinase Inhibitor for Skin Lightening. Preprints2024, 2024101006. https://doi.org/10.20944/preprints202410.1006.v1
APA Style
Chang, H., Tao, K., Huang, H., Jia, J., Khan, S. N., & Cui, J. (2024). Discovery of A Novel Cyclopeptide as Tyrosinase Inhibitor for Skin Lightening. Preprints. https://doi.org/10.20944/preprints202410.1006.v1
Chicago/Turabian Style
Chang, H., Shah Nawaz Khan and Jiahua Cui. 2024 "Discovery of A Novel Cyclopeptide as Tyrosinase Inhibitor for Skin Lightening" Preprints. https://doi.org/10.20944/preprints202410.1006.v1
Abstract
Melanin content significantly influences the skin-lightening effects of active ingredients, with inhibition of melanin synthesis contributing to skin-lightening effects. This study evaluates the effects of novel cyclopeptide CHP-9 as a safe and potent human tyrosinase inhibitor. CHP-9 showed a significant inhibition rate of approximately 28.57% at 1% concentration. The melanin formation assay, upon exposure to CHP-9 alone, resulted in a reduction of cellular melanin content from 30.90±1.13 μg/mL to 23.51±1.14 μg/mL. Additionally, in silico molecular docking experiments were conducted to verify the tyrosinase inhibitory activity of the cyclopeptide CHP-9 on tyrosinase and it was observed that hydrogen bonding is pivotal in the binding affinity of CHP-9 with the target enzyme in docking. These results suggest that the cyclopeptide CHP-9 may serve as a valuable bioactive compound for skin-lightening agents in cosmetics applications, specifically in reducing melanin production.
Keywords
Cyclopeptide; tyrosinase inhibitors; chemical synthesis; molecular docking; skin lightening; cosmetics
Subject
Medicine and Pharmacology, Dermatology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
