Version 1
: Received: 12 October 2024 / Approved: 13 October 2024 / Online: 15 October 2024 (03:44:32 CEST)
How to cite:
Rohokale, R.; Mane, R. A Comprehensive Achievement in the Total Synthesis of Antibacterial Furanomycin and Its Analogs. Preprints2024, 2024101029. https://doi.org/10.20944/preprints202410.1029.v1
Rohokale, R.; Mane, R. A Comprehensive Achievement in the Total Synthesis of Antibacterial Furanomycin and Its Analogs. Preprints 2024, 2024101029. https://doi.org/10.20944/preprints202410.1029.v1
Rohokale, R.; Mane, R. A Comprehensive Achievement in the Total Synthesis of Antibacterial Furanomycin and Its Analogs. Preprints2024, 2024101029. https://doi.org/10.20944/preprints202410.1029.v1
APA Style
Rohokale, R., & Mane, R. (2024). A Comprehensive Achievement in the Total Synthesis of Antibacterial Furanomycin and Its Analogs. Preprints. https://doi.org/10.20944/preprints202410.1029.v1
Chicago/Turabian Style
Rohokale, R. and Rajendra Mane. 2024 "A Comprehensive Achievement in the Total Synthesis of Antibacterial Furanomycin and Its Analogs" Preprints. https://doi.org/10.20944/preprints202410.1029.v1
Abstract
L-(+)-Furanomycin 1 is a miniature antibacterial natural product that contains an -amino acid core. This non-proteinogenic α-amino acid was first isolated in 1967 by Katagiri and co-workers from the fermentation broth of Streptomyces threomyceticus L-803 (ATCC 15795). It is a substrate of isoleucyl aminoacyl tRNA synthetase that replaces isoleucine in the protein translation process and exhibits antibacterial properties in vitro. It effectively acts as an antibacterial agent against M. tuberculosis, E. coli, B. subtilis, and some Shigella and Salmonella bacterial species at concentrations as low as the micromolar range. Consequently, synthetic chemists have garnered considerable interest from their specific structure-activity profile, distinctive chemical compositions, and distinct biological profile. This review comprehensively describes cutting-edge synthetic methodologies for synthesizing furanomycin and its analogs reported to date. Therefore, this review will offer an initial perspective on synthesizing furanomycin and its customized compounds.
Keywords
Furanomycin; non-proteinogenic amino acids; antibiotics natural products; total synthesis
Subject
Chemistry and Materials Science, Organic Chemistry
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
