Version 1
: Received: 12 October 2024 / Approved: 14 October 2024 / Online: 14 October 2024 (13:40:21 CEST)
How to cite:
Ha, R.; Cho, W. K.; Kim, E.; Jang, S. J.; Kim, J.-D.; Yi, C.-G.; Moh, S. H. Exploring the Benefits of Herbal Medicine Composite 5 (HRMC5) for Skin Health Enhancement. Preprints2024, 2024101068. https://doi.org/10.20944/preprints202410.1068.v1
Ha, R.; Cho, W. K.; Kim, E.; Jang, S. J.; Kim, J.-D.; Yi, C.-G.; Moh, S. H. Exploring the Benefits of Herbal Medicine Composite 5 (HRMC5) for Skin Health Enhancement. Preprints 2024, 2024101068. https://doi.org/10.20944/preprints202410.1068.v1
Ha, R.; Cho, W. K.; Kim, E.; Jang, S. J.; Kim, J.-D.; Yi, C.-G.; Moh, S. H. Exploring the Benefits of Herbal Medicine Composite 5 (HRMC5) for Skin Health Enhancement. Preprints2024, 2024101068. https://doi.org/10.20944/preprints202410.1068.v1
APA Style
Ha, R., Cho, W. K., Kim, E., Jang, S. J., Kim, J. D., Yi, C. G., & Moh, S. H. (2024). Exploring the Benefits of Herbal Medicine Composite 5 (HRMC5) for Skin Health Enhancement. Preprints. https://doi.org/10.20944/preprints202410.1068.v1
Chicago/Turabian Style
Ha, R., Chang-Geun Yi and Sang Hyun Moh. 2024 "Exploring the Benefits of Herbal Medicine Composite 5 (HRMC5) for Skin Health Enhancement" Preprints. https://doi.org/10.20944/preprints202410.1068.v1
Abstract
The skin, as the body's largest organ, is vital for protecting against environmental stressors, regulating temperature, and preventing water loss. Maintaining a healthy skin barrier is essential for overall skin health and function. We examined the potential of a mixture of five traditional Korean herbal extracts—Cimicifuga racemosa, Paeonia lactiflora, Phellodendron amurense, Rheum rhaponticum, and Scutellaria baicalensis— referred to as herbal medicine composite 5 (HRMC5) for enhancing skin health. High-performance liquid chromatography identified 14 bioactive compounds, including flavonoids, phenolic acids, anthraquinones, and alkaloids, known for their antioxidant, anti-inflammatory, and antimicrobial effects. The extract showed concentration-dependent effects on cell viability and provided UV protection at 6.25 g/L. It also significantly promoted wound healing, similar to the efficacy of epidermal growth factor. Furthermore, the mixture exhibited anti-inflammatory activity by downregulating Cox2 expression and upregulated key skin barrier proteins, including Involucrin, Claudin 1, and Collagen Type 1. These findings highlight the potential of this herbal mixture for addressing skin barrier dysfunction, inflammation, and facial redness, supporting its use in developing natural skincare products. Future studies should investigate the mechanisms behind these effects and assess its clinical applications.
Keywords
traditional Korean herbal extracts; anti-inflammatory properties; skin barrier function; wound healing; UV protection
Subject
Biology and Life Sciences, Life Sciences
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
