Alloantibody Identification: The Importance of Temperature, Strength Reaction and Enzymes—A Pratical Approach

Palma Manduzio

doi:10.20944/preprints202410.1146.v1

Preprint Article Version 1 This version is not peer-reviewed

Version 1 : Received: 14 October 2024 / Approved: 15 October 2024 / Online: 15 October 2024 (07:29:54 CEST)

Red blood cell (RBC) alloimmunization and antibodies formation against non-self-antigen on red cells may occur after blood transfusion, pregnancies or other exposures. The RBC alloimmunization rates varies from 2% to 6% according to recent studies. The antibody screen is performed to identify or confirm the presence of antibodies in patient’s serum or plasma, as a preoperative or pretransfusion tests. The antibody identification process and major crossmatch are provided to improve the safety of red blood transfusion administration. I report three examples associated with clinically significant single and multiple alloantibodies. Ultimately, I summarize key points for a clinical transfusion practice.

red blood cell alloimmunization; antibody identification; transfusion safety

Public Health and Healthcare, Public Health and Health Services

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Alloantibody Identification: The Importance of Temperature, Strength Reaction and Enzymes—A Pratical Approach

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