Recombinant Live-Attenuated Salmonella Vaccine for Veterinary Use

Domitila Brzoskowski Chagas; Francisco Denis Souza Santos; Natasha Rodrigues de Oliveira; Thaís Larré Oliveira Bohn; Odir Antônio Dellagostin

doi:10.20944/preprints202410.1420.v1

Preprint Review Version 1 This version is not peer-reviewed

Version 1 : Received: 17 October 2024 / Approved: 17 October 2024 / Online: 18 October 2024 (08:23:18 CEST)

Vaccination is essential in maintaining animal health, with a priority on safety and cost-effectiveness in veterinary vaccines. The development of recombinant live-attenuated Salmonella vaccines (RASVs) has enabled the construction of balanced lethal systems, ensuring the stability of plasmid vectors encoding protective antigens post-immunization. These vaccines are particularly suitable for production animals, providing long-term immunity against a range of bacterial, viral, and parasitic pathogens. This review summarizes the progress made in this field, with a focus on clinical trials demonstrating the efficacy and commercial potential of RASVs in veterinary medicine.

vaccine development; Salmonella; attenuation; RASV; animal

Biology and Life Sciences, Immunology and Microbiology

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Recombinant Live-Attenuated Salmonella Vaccine for Veterinary Use

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