PreprintReviewVersion 1This version is not peer-reviewed
Antigen Delivery Platforms for Next-Generation Coronavirus Vaccines:
The Superiority of Nucleoside-Modified mRNA Encapsulated in Lipid Nanoparticles Vaccine Platform
Version 1
: Received: 21 October 2024 / Approved: 21 October 2024 / Online: 21 October 2024 (12:01:17 CEST)
How to cite:
Chentoufi, A. A.; Ulmer, J. B.; BenMohamed, L. Antigen Delivery Platforms for Next-Generation Coronavirus Vaccines:
The Superiority of Nucleoside-Modified mRNA Encapsulated in Lipid Nanoparticles Vaccine Platform. Preprints2024, 2024101560. https://doi.org/10.20944/preprints202410.1560.v1
Chentoufi, A. A.; Ulmer, J. B.; BenMohamed, L. Antigen Delivery Platforms for Next-Generation Coronavirus Vaccines:
The Superiority of Nucleoside-Modified mRNA Encapsulated in Lipid Nanoparticles Vaccine Platform. Preprints 2024, 2024101560. https://doi.org/10.20944/preprints202410.1560.v1
Chentoufi, A. A.; Ulmer, J. B.; BenMohamed, L. Antigen Delivery Platforms for Next-Generation Coronavirus Vaccines:
The Superiority of Nucleoside-Modified mRNA Encapsulated in Lipid Nanoparticles Vaccine Platform. Preprints2024, 2024101560. https://doi.org/10.20944/preprints202410.1560.v1
APA Style
Chentoufi, A. A., Ulmer, J. B., & BenMohamed, L. (2024). Antigen Delivery Platforms for Next-Generation Coronavirus Vaccines:
The Superiority of Nucleoside-Modified mRNA Encapsulated in Lipid Nanoparticles Vaccine Platform. Preprints. https://doi.org/10.20944/preprints202410.1560.v1
Chicago/Turabian Style
Chentoufi, A. A., Jeffrey B. Ulmer and Lbachir BenMohamed. 2024 "Antigen Delivery Platforms for Next-Generation Coronavirus Vaccines:
The Superiority of Nucleoside-Modified mRNA Encapsulated in Lipid Nanoparticles Vaccine Platform" Preprints. https://doi.org/10.20944/preprints202410.1560.v1
Abstract
The COVID-19 pandemic, caused by the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), is in its 5th year and is being maintained by the inability of current spike-alone based COVID-19 vaccines to prevent transmission leading to the continuous emergence of variants and sub-variants of concern (VOCs). This underscores the critical need for next-generation broad-spectrum pan-Coronavirus vaccines (pan-CoV vaccine) to break this cycle and end the pandemic. The development of a pan-CoV vaccine offering protection against a wide array of VOCs requires two key elements: (1) identifying protective antigens that are highly conserved between passed, current and future VOCs; and (2) developing a safe and efficient antigens deliver system for induction of broad-based B- and T-cell immunity. This review will (1) present the current state of antigen delivery platforms involving a multifaceted approach, including bioinformatics, molecular and structural biology, immunology, and advanced computational methods; (2) discuss the challenges facing development of safe and effective antigen delivery platforms; and (3) highlight the potential of nucleoside-modified mRNA encapsulated in lipid nanoparticles (LNP) as the platform that is well suited to the needs of a next-generation pan-CoV vaccine, such as the ability to induce broad-based immunity and amenable to large-scale manufacturing to safely provide durable protective immunity against current and future Coronavirus threats.
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
