Version 1
: Received: 22 October 2024 / Approved: 23 October 2024 / Online: 24 October 2024 (08:28:08 CEST)
How to cite:
Papp, M.; Ince, C.; Bakker, J.; Molnar, Z. Endothelial Protection and Improved Micro- and Macrocirculation with Hemoadsorption in Critically Ill Patients. Preprints2024, 2024101821. https://doi.org/10.20944/preprints202410.1821.v1
Papp, M.; Ince, C.; Bakker, J.; Molnar, Z. Endothelial Protection and Improved Micro- and Macrocirculation with Hemoadsorption in Critically Ill Patients. Preprints 2024, 2024101821. https://doi.org/10.20944/preprints202410.1821.v1
Papp, M.; Ince, C.; Bakker, J.; Molnar, Z. Endothelial Protection and Improved Micro- and Macrocirculation with Hemoadsorption in Critically Ill Patients. Preprints2024, 2024101821. https://doi.org/10.20944/preprints202410.1821.v1
APA Style
Papp, M., Ince, C., Bakker, J., & Molnar, Z. (2024). Endothelial Protection and Improved Micro- and Macrocirculation with Hemoadsorption in Critically Ill Patients. Preprints. https://doi.org/10.20944/preprints202410.1821.v1
Chicago/Turabian Style
Papp, M., Jan Bakker and Zsolt Molnar. 2024 "Endothelial Protection and Improved Micro- and Macrocirculation with Hemoadsorption in Critically Ill Patients" Preprints. https://doi.org/10.20944/preprints202410.1821.v1
Abstract
A dysregulated immune response is associated with the excessive release of cytokines that can lead to systemic vasoplegia and vasoplegic shock with the development of multiorgan failure that is associated with an increased risk of dying. Under physiological circumstances, the endothelium and the glycocalyx are responsible for maintaining vascular tone, capillary permeability, hemostasis, and controlling inflammation. In hyperinflammation, the endothelium and glycocalyx become damaged due to the excessive production of certain toxic proteins, along with an overwhelming release of cytokines. It has been shown in both in vitro animal experiments and also in humans that extracorporeal hemoadsorption can reduce circulating levels of cytokines and may also remove toxic proteins that directly take part in endothelium and glycocalyx damage. The current review aims to summarize current knowledge and to put recent findings into context, and introduce the hypothesis of “endothelial protection with hemoadsorption” in critically ill patients.
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
