Exploring the Impact of Plant-Derived Antioxidants on Heart Aging: A Mechanistic Outlook

Muneer Ahmed Khoso; Heng Liu; Tong Zhao; Wenjie Zhao; Qiang Huang; Zeqi Sun; Khuzin Dinislam; Mohammad Omar; Yong Zhang; Xin Liu

doi:10.20944/preprints202410.1877.v1

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preprints.org > medicine and pharmacology > medicine and pharmacology > doi: 10.20944/preprints202410.1877.v1

Preprint Review Version 1 This version is not peer-reviewed

Exploring the Impact of Plant-Derived Antioxidants on Heart Aging: A Mechanistic Outlook

^* ,

Version 1 : Received: 22 October 2024 / Approved: 23 October 2024 / Online: 24 October 2024 (09:50:12 CEST)

How to cite: Khoso, M. A.; Liu, H.; Zhao, T.; Zhao, W.; Huang, Q.; Sun, Z.; Dinislam, K.; Omar, M.; Zhang, Y.; Liu, X. Exploring the Impact of Plant-Derived Antioxidants on Heart Aging: A Mechanistic Outlook. Preprints 2024, 2024101877. https://doi.org/10.20944/preprints202410.1877.v1 Khoso, M. A.; Liu, H.; Zhao, T.; Zhao, W.; Huang, Q.; Sun, Z.; Dinislam, K.; Omar, M.; Zhang, Y.; Liu, X. Exploring the Impact of Plant-Derived Antioxidants on Heart Aging: A Mechanistic Outlook. Preprints 2024, 2024101877. https://doi.org/10.20944/preprints202410.1877.v1

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MDPI and ACS Style

Khoso, M. A.; Liu, H.; Zhao, T.; Zhao, W.; Huang, Q.; Sun, Z.; Dinislam, K.; Omar, M.; Zhang, Y.; Liu, X. Exploring the Impact of Plant-Derived Antioxidants on Heart Aging: A Mechanistic Outlook. Preprints 2024, 2024101877. https://doi.org/10.20944/preprints202410.1877.v1

APA Style

Khoso, M. A., Liu, H., Zhao, T., Zhao, W., Huang, Q., Sun, Z., Dinislam, K., Omar, M., Zhang, Y., & Liu, X. (2024). Exploring the Impact of Plant-Derived Antioxidants on Heart Aging: A Mechanistic Outlook. Preprints. https://doi.org/10.20944/preprints202410.1877.v1

Chicago/Turabian Style

Khoso, M. A., Yong Zhang and Xin Liu. 2024 "Exploring the Impact of Plant-Derived Antioxidants on Heart Aging: A Mechanistic Outlook" Preprints. https://doi.org/10.20944/preprints202410.1877.v1

Abstract

Heart aging involves a complex interplay of genetic and environmental influences, leading to a gradual deterioration of cardiovascular integrity and function. Age-related physiological changes, including ventricular hypertrophy, diastolic dysfunction, myocardial fibrosis, increased arterial stiffness, and endothelial dysfunction, are influenced by key mechanisms like autophagy, inflammation, and oxidative stress. This review aims to explore the therapeutic potential of plant-derived bioactive antioxidants in mitigating heart aging. These compounds, often rich in polyphenols, flavonoids, and other phytochemicals, exhibit notable antioxidant, anti-inflammatory, and cardioprotective properties. Through a comprehensive analysis of preclinical and clinical studies, this work highlights the mechanisms associated with heart aging and the promising effects of plant-derived antioxidants. The findings may helpful for researchers in identifying specific molecules with therapeutic and preventive potential for cardiovascular aging.

Keywords

cardiac aging; cardiac alterations; antioxidants; mechanism; reactive oxygen species

Subject

Medicine and Pharmacology, Medicine and Pharmacology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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