Mitev, V.; Mondeshki, T.; Miteva, A.; Tashkov, K.; Dimitrova, V. COVID-19 Prophylactic Effect of Bromhexine Hydrochloride. Preprints2024, 2024101998. https://doi.org/10.20944/preprints202410.1998.v1
APA Style
Mitev, V., Mondeshki, T., Miteva, A., Tashkov, K., & Dimitrova, V. (2024). COVID-19 Prophylactic Effect of Bromhexine Hydrochloride. Preprints. https://doi.org/10.20944/preprints202410.1998.v1
Chicago/Turabian Style
Mitev, V., Konstantin Tashkov and Violeta Dimitrova. 2024 "COVID-19 Prophylactic Effect of Bromhexine Hydrochloride" Preprints. https://doi.org/10.20944/preprints202410.1998.v1
Abstract
Despite the enormous efforts and funds spent to find an effective treatment for COVID-19, the results have been disappointing. In previous publications, we have demonstrated the remarkable effect of high-dose colchicine in inhibiting the cytokine storm and preventing multiorgan damage and death. However, this treatment is beneficial only after virus entry into the cell. The question of prophylaxis and entry prohibition should also be explored. We now demonstrate the prophylactic effect of bromhexine hydrochloride (BRH), an over-the-counter, non-invasive, effective, well-tolerated medicine, with proven safety, affordable, and inexpensive on 125 men and women. The effect of BRH is best when given continuously for prophylaxis during peaks in contagion in the wave of COVID-19. Then the probability of infection drops sharply, and if a disease does occur, it proceeds mildly. BRH is also effective when given by inhalation for post-exposure prophylaxis.When COVID-19 manifests itself clinically, the efficacy of BRH drops sharply because the virus is already in the cell. However, BRH inhalations are useful because they limit the spread of the virus and have an anti-inflammatory and possibly antiviral effect.
Keywords
COVID-19; Bromhexine; TMPRSS2; Prophylactics
Subject
Medicine and Pharmacology, Epidemiology and Infectious Diseases
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
