Version 1
: Received: 24 October 2024 / Approved: 25 October 2024 / Online: 25 October 2024 (11:28:19 CEST)
How to cite:
Petrov, K. T.; Ivanov, I. N.; Popovska, S. L.; Betova, T. M.; Kamburova, Z. B. Colorectal Cancer: A Brief and Simplified Analysis of a Complex Disease. Preprints2024, 2024102029. https://doi.org/10.20944/preprints202410.2029.v1
Petrov, K. T.; Ivanov, I. N.; Popovska, S. L.; Betova, T. M.; Kamburova, Z. B. Colorectal Cancer: A Brief and Simplified Analysis of a Complex Disease. Preprints 2024, 2024102029. https://doi.org/10.20944/preprints202410.2029.v1
Petrov, K. T.; Ivanov, I. N.; Popovska, S. L.; Betova, T. M.; Kamburova, Z. B. Colorectal Cancer: A Brief and Simplified Analysis of a Complex Disease. Preprints2024, 2024102029. https://doi.org/10.20944/preprints202410.2029.v1
APA Style
Petrov, K. T., Ivanov, I. N., Popovska, S. L., Betova, T. M., & Kamburova, Z. B. (2024). Colorectal Cancer: A Brief and Simplified Analysis of a Complex Disease. Preprints. https://doi.org/10.20944/preprints202410.2029.v1
Chicago/Turabian Style
Petrov, K. T., Tatjana Marinova Betova and Zornica Bogomilova Kamburova. 2024 "Colorectal Cancer: A Brief and Simplified Analysis of a Complex Disease" Preprints. https://doi.org/10.20944/preprints202410.2029.v1
Abstract
In this study we summarized our work on various aspects of colorectal adenocarcinomas, 1
focusing on tumor distribution (left- sided, right- sided, and rectal cancers), histologycal type, patient 2
age, gender and several factors affecting prognosis. These predictive and prognostic factors include 3
peritumoral budding, lymphovascular ant perineural invasion, lymph node metastasis, mismatch 4
repair status, and corellations with some frequently known mutations in colorectal adenocarcinomas, 5
detected using Next- Generation Sequencing (NGS) platform. This comprehensive approach allowed 6
us to explore how these factors interplay and influence the clinical outcome of patients with colorectal 7
adenocarcinoma. Additionaly, our findings contribute to the understanding of how genetic mutations 8
may correlate with histological features and prognostic markers, potentially guiding personalized 9
treatment strategies in the future. In our study, we do not claim to have exhausted the research on 10
the topic, and we fully recognized the need for more extensive and in-depth studies in this area of 11
tumor pathology.
Keywords
colorectal adenocarcinoma; left and right- sided; histologic type; peritumoral budding; 13 lymphovascular and perineural invasion; lymph node metastasis; MMR status; mutations; NGS
Subject
Medicine and Pharmacology, Pathology and Pathobiology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
,
,
,
,
