Version 1
: Received: 25 October 2024 / Approved: 25 October 2024 / Online: 25 October 2024 (13:27:32 CEST)
How to cite:
Tangchang, W.; Jung, G. Y.; Song, J. Y.; Kumbukgahadeniya, P.; Kwon, H. J.; Son, H.-Y. Endocrine Mucin-Producing Sweat Gland Carcinoma (EMPSGC) in a Dog: Immunohistochemical Characterization and Diagnostic Approach. Preprints2024, 2024102030. https://doi.org/10.20944/preprints202410.2030.v1
Tangchang, W.; Jung, G. Y.; Song, J. Y.; Kumbukgahadeniya, P.; Kwon, H. J.; Son, H.-Y. Endocrine Mucin-Producing Sweat Gland Carcinoma (EMPSGC) in a Dog: Immunohistochemical Characterization and Diagnostic Approach. Preprints 2024, 2024102030. https://doi.org/10.20944/preprints202410.2030.v1
Tangchang, W.; Jung, G. Y.; Song, J. Y.; Kumbukgahadeniya, P.; Kwon, H. J.; Son, H.-Y. Endocrine Mucin-Producing Sweat Gland Carcinoma (EMPSGC) in a Dog: Immunohistochemical Characterization and Diagnostic Approach. Preprints2024, 2024102030. https://doi.org/10.20944/preprints202410.2030.v1
APA Style
Tangchang, W., Jung, G. Y., Song, J. Y., Kumbukgahadeniya, P., Kwon, H. J., & Son, H. Y. (2024). Endocrine Mucin-Producing Sweat Gland Carcinoma (EMPSGC) in a Dog: Immunohistochemical Characterization and Diagnostic Approach. Preprints. https://doi.org/10.20944/preprints202410.2030.v1
Chicago/Turabian Style
Tangchang, W., Hyo Jung Kwon and Hwa-Young Son. 2024 "Endocrine Mucin-Producing Sweat Gland Carcinoma (EMPSGC) in a Dog: Immunohistochemical Characterization and Diagnostic Approach" Preprints. https://doi.org/10.20944/preprints202410.2030.v1
Abstract
A seven-year-old spayed female dog presented with multiple, small spindle-shaped masses on the abdominal skin. The excised tissue was submitted for histopathological evaluation. Routine his-tology revealed basaloid nodules with stippled chromatin and pleomorphic nuclei. Mor-pho-logically, the tumor resembled a solid papillary carcinoma of the breast or an endocrine mucin-producing sweat gland carcinoma (EMPSGC). EMPSGC is a rare neuroendo-crine-differentiated neoplasm. This study aimed to compare different immunohistochemical markers for distinguishing between canine sweat gland carcinoma (SGC) and mammary gland carcinoma (MGC). CK19 and Sox9 were useful in identifying SGC. Additionally, the tumor was positive for CK5, AE1/AE3+CK8/18, p63, vimentin, E-cadherin, and synaptophysin, while estrogen receptor staining was negative. The final diagnosis of canine EMPSGC was based on the tumor’s morphological and neuroendocrine immunohistopathological features. Our report provides the first detailed description of a canine EMPSGC, an exceedingly rare tumor in dogs.
Medicine and Pharmacology, Pathology and Pathobiology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.